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Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts
Zhuo, De Xiang1; Niu, Xiao Hua2,3; Chen, Yi Cheng2,3; Xin, Dian Qi2,3; Guo, Ying Lu2,3; Mao, Ze Bin1
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2010-10-08
DOI10.1074/jbc.M109.068387
285期:41页:31491-31501
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]THIOREDOXIN-BINDING PROTEIN-2 ; REPLICATIVE SENESCENCE ; CELLULAR SENESCENCE ; OXIDATIVE STRESS ; MESSENGER-RNA ; EXPRESSION ; CANCER ; GROWTH ; CELLS ; GENE
英文摘要

Vitamin D-3 up-regulated protein 1 (VDUP1) plays multifunctional roles in diverse cellular responses, particularly in its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases. In this study, we demonstrated that VDUP1 was up-regulated during the senescence process. Our results showed that overexpression of VDUP1 in young cells caused typical signs of senescence. We also found that VDUP1 knockdown delayed the onset of Ras-induced cellular senescence. Subsequently, we found that FOXO3A, whose activity increased in senescent cells, transcriptionally up-regulates VDUP1 expression and miR-17-5p, whose expression decreased in senescent cells, directly interacted with the 3′-un-translated region of VDUP1 transcripts, and destabilized VDUP1 mRNA in young cells. These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process.

语种英语
WOS记录号WOS:000282764600043
项目编号2007CB507400 ; 30672201 ; 306210021
资助机构National Basic Research Programs of China ; National Science Foundation of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53880
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Dept Urol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Zhuo, De Xiang,Niu, Xiao Hua,Chen, Yi Cheng,et al. Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2010,285(41):31491-31501.
APA Zhuo, De Xiang,Niu, Xiao Hua,Chen, Yi Cheng,Xin, Dian Qi,Guo, Ying Lu,&Mao, Ze Bin.(2010).Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts.JOURNAL OF BIOLOGICAL CHEMISTRY,285(41),31491-31501.
MLA Zhuo, De Xiang,et al."Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts".JOURNAL OF BIOLOGICAL CHEMISTRY 285.41(2010):31491-31501.
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