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学科主题: 临床医学
题名:
Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts
作者: Zhuo, De Xiang1; Niu, Xiao Hua2,3; Chen, Yi Cheng2,3; Xin, Dian Qi2,3; Guo, Ying Lu2,3; Mao, Ze Bin1
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2010-10-08
DOI: 10.1074/jbc.M109.068387
卷: 285, 期:41, 页:31491-31501
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: THIOREDOXIN-BINDING PROTEIN-2 ; REPLICATIVE SENESCENCE ; CELLULAR SENESCENCE ; OXIDATIVE STRESS ; MESSENGER-RNA ; EXPRESSION ; CANCER ; GROWTH ; CELLS ; GENE
英文摘要:

Vitamin D-3 up-regulated protein 1 (VDUP1) plays multifunctional roles in diverse cellular responses, particularly in its relation to proliferation, apoptosis, differentiation, and diseases such as cancer and stress-related diseases. In this study, we demonstrated that VDUP1 was up-regulated during the senescence process. Our results showed that overexpression of VDUP1 in young cells caused typical signs of senescence. We also found that VDUP1 knockdown delayed the onset of Ras-induced cellular senescence. Subsequently, we found that FOXO3A, whose activity increased in senescent cells, transcriptionally up-regulates VDUP1 expression and miR-17-5p, whose expression decreased in senescent cells, directly interacted with the 3′-un-translated region of VDUP1 transcripts, and destabilized VDUP1 mRNA in young cells. These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process.

语种: 英语
所属项目编号: 2007CB507400 ; 30672201 ; 306210021
项目资助者: National Basic Research Programs of China ; National Science Foundation of China
WOS记录号: WOS:000282764600043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53880
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Dept Urol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhuo, De Xiang,Niu, Xiao Hua,Chen, Yi Cheng,et al. Vitamin D-3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2010,285(41):31491-31501.
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