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学科主题: 临床医学
题名:
Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients
作者: Wang, Zheng1; Liang, Xu1; Yu, Jing1; Zheng, Xiaohui1; Zhu, Yulin1; Yan, Ying1; Dong, Ningning1; Di, Lijun1; Song, Guohong1; Zhou, Xinna1; Wang, Xiaoli1; Yang, Huabing1; Ren, Jun1; Lyerly, Herbert Kim2
关键词: breast cancer ; docetaxel ; drug-induced liver injury ; epidemiology
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2012-08-01
DOI: 10.1111/j.1440-1746.2012.07131.x
卷: 27, 期:8, 页:1348-1352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ORAL MEDICATIONS ; DISEASE ; CHEMOTHERAPY ; HEPATITIS
英文摘要:

Background and Aim: Docetaxel has been chosen as one of the most popular anticancer drugs in the treatment of breast cancer for more than a decade. There is increasingly awareness for the occurrence of docetaxel and/or docetaxeldrug-induced liver injury (DILI), although the underlying mechanism of occurrence and its risk factors remain unclear. Methods: We conducted a retrospective cohort study to identify non-genetic risk factors for docetaxelDILI among 647 metastasis breast cancer patients treated with docetaxel-containing regimens. Results: Sixty-seven (10.36%) patients were diagnosed as docetaxelDILI. By logistic regression analysis, premenopausal status (odds ratio [OR][95% confidence interval {CI}] = 2.24 [1.303.87]), past hepatitis B virus (HBV) infections (OR [95% CI] = 4.23 [1.5711.42]), liver metastasis (OR [95% CI] = 3.70 [2.166.34]). The predominant occurrence of DILI was seen in groups with docetaxel combination regimens. (OR [95% CI] = 2.66 [1.594.55]). The potential increasing occurrence of docetaxelDILI was associated with multiple risk factors in an exposureresponse manner (P < 0.001), and patients with more than three risk factors would be exposed to a 36.61-fold risk of DILI (95% CI = 10.18131.62). Further analysis by the risk score and area under the receiveroperator characteristic curve (AUC) showed that those four factors contributed to an AUC of 0.7536 (95% CI = 0.700.81), with a predictive sensitivity of 74.63% and specificity of 65.17%. Conclusions: DocetaxelDILI with a relatively higher incidence should be addressed among metastatic breast cancer patients. Four predominant risk factors, including premenopausal status, past HBV infection, liver metastasis, and docetaxel combination regimens, were potential predicators for DILI.

语种: 英语
所属项目编号: 2011ZX09302-001-02
项目资助者: Chinese National Science and Technology Major Project, Mega-Project for New Drugs Development
WOS记录号: WOS:000306650700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53884
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Med Oncol, Beijing 100142, Peoples R China
2.Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Durham, NC 27710 USA

Recommended Citation:
Wang, Zheng,Liang, Xu,Yu, Jing,et al. Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2012,27(8):1348-1352.
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