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学科主题临床医学
Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients
Wang, Zheng1; Liang, Xu1; Yu, Jing1; Zheng, Xiaohui1; Zhu, Yulin1; Yan, Ying1; Dong, Ningning1; Di, Lijun1; Song, Guohong1; Zhou, Xinna1; Wang, Xiaoli1; Yang, Huabing1; Ren, Jun1; Lyerly, Herbert Kim2
关键词Breast Cancer Docetaxel Drug-induced Liver Injury Epidemiology
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2012-08-01
DOI10.1111/j.1440-1746.2012.07131.x
27期:8页:1348-1352
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Chinese National Science and Technology Major Project, Mega-Project for New Drugs Development ; Chinese National Science and Technology Major Project, Mega-Project for New Drugs Development
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ORAL MEDICATIONS ; DISEASE ; CHEMOTHERAPY ; HEPATITIS
英文摘要

Background and Aim: Docetaxel has been chosen as one of the most popular anticancer drugs in the treatment of breast cancer for more than a decade. There is increasingly awareness for the occurrence of docetaxel and/or docetaxeldrug-induced liver injury (DILI), although the underlying mechanism of occurrence and its risk factors remain unclear. Methods: We conducted a retrospective cohort study to identify non-genetic risk factors for docetaxelDILI among 647 metastasis breast cancer patients treated with docetaxel-containing regimens. Results: Sixty-seven (10.36%) patients were diagnosed as docetaxelDILI. By logistic regression analysis, premenopausal status (odds ratio [OR][95% confidence interval {CI}] = 2.24 [1.303.87]), past hepatitis B virus (HBV) infections (OR [95% CI] = 4.23 [1.5711.42]), liver metastasis (OR [95% CI] = 3.70 [2.166.34]). The predominant occurrence of DILI was seen in groups with docetaxel combination regimens. (OR [95% CI] = 2.66 [1.594.55]). The potential increasing occurrence of docetaxelDILI was associated with multiple risk factors in an exposureresponse manner (P < 0.001), and patients with more than three risk factors would be exposed to a 36.61-fold risk of DILI (95% CI = 10.18131.62). Further analysis by the risk score and area under the receiveroperator characteristic curve (AUC) showed that those four factors contributed to an AUC of 0.7536 (95% CI = 0.700.81), with a predictive sensitivity of 74.63% and specificity of 65.17%. Conclusions: DocetaxelDILI with a relatively higher incidence should be addressed among metastatic breast cancer patients. Four predominant risk factors, including premenopausal status, past HBV infection, liver metastasis, and docetaxel combination regimens, were potential predicators for DILI.

语种英语
所属项目编号2011ZX09302-001-02
资助者Chinese National Science and Technology Major Project, Mega-Project for New Drugs Development ; Chinese National Science and Technology Major Project, Mega-Project for New Drugs Development
WOS记录号WOS:000306650700016
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53884
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Med Oncol, Beijing 100142, Peoples R China
2.Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Durham, NC 27710 USA
推荐引用方式
GB/T 7714
Wang, Zheng,Liang, Xu,Yu, Jing,et al. Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2012,27(8):1348-1352.
APA Wang, Zheng.,Liang, Xu.,Yu, Jing.,Zheng, Xiaohui.,Zhu, Yulin.,...&Lyerly, Herbert Kim.(2012).Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,27(8),1348-1352.
MLA Wang, Zheng,et al."Non-genetic risk factors and predicting efficacy for docetaxel-drug-induced liver injury among metastatic breast cancer patients".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27.8(2012):1348-1352.
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