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学科主题: 临床医学
题名:
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
作者: Zhao, Ying1; Yang, Jing1; Liao, Wenjuan1; Liu, Xiangyu1; Zhang, Hui1,2; Wang, Shan2; Wang, Donglai1; Feng, Jingnan1; Yu, Li3; Zhu, Wei-Guo1,5
刊名: NATURE CELL BIOLOGY
发表日期: 2010-07-01
DOI: 10.1038/ncb2069
卷: 12, 期:7, 页:665-U88
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: FORKHEAD TRANSCRIPTION FACTOR ; CELL-DEATH ; C-ELEGANS ; LIFE-SPAN ; DEACETYLASE ACTIVITY ; SELF-DIGESTION ; GENE ; TUMORIGENESIS ; BECLIN-1 ; ACTIVATION
英文摘要:

Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but this process was independent of the transcriptional activity of FoxO1. In response to stress, FoxO1 was acetylated by dissociation from sirtuin-2 (SIRT2), a NAD(+)-dependent histone deacetylase, and the acetylated FoxO1 bound to Atg7, an E1-following protein, to influence the autophagic process leading to cell death. This FoxO1-modulated cell death is associated with tumour suppressor activity in human colon tumours and a xenograft mouse model. Our finding links the anti-neoplastic activity of FoxO1 and the process of autophagy.

语种: 英语
WOS记录号: WOS:000279374400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53888
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Tsinghua Univ, Dept Biol Sci, Beijing 100084, Peoples R China
2.Peking Univ, Beijing 00142, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Surg, Affiliated Hosp 2, Beijing 100044, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Sch Oncol, Beijing 00142, Peoples R China

Recommended Citation:
Zhao, Ying,Yang, Jing,Liao, Wenjuan,et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity[J]. NATURE CELL BIOLOGY,2010,12(7):665-U88.
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