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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
Zhao, Ying1; Yang, Jing1; Liao, Wenjuan1; Liu, Xiangyu1; Zhang, Hui1,2; Wang, Shan2; Wang, Donglai1; Feng, Jingnan1; Yu, Li3; Zhu, Wei-Guo1,5
刊名NATURE CELL BIOLOGY
2010-07-01
DOI10.1038/ncb2069
12期:7页:665-U88
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]FORKHEAD TRANSCRIPTION FACTOR ; CELL-DEATH ; C-ELEGANS ; LIFE-SPAN ; DEACETYLASE ACTIVITY ; SELF-DIGESTION ; GENE ; TUMORIGENESIS ; BECLIN-1 ; ACTIVATION
英文摘要

Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but this process was independent of the transcriptional activity of FoxO1. In response to stress, FoxO1 was acetylated by dissociation from sirtuin-2 (SIRT2), a NAD(+)-dependent histone deacetylase, and the acetylated FoxO1 bound to Atg7, an E1-following protein, to influence the autophagic process leading to cell death. This FoxO1-modulated cell death is associated with tumour suppressor activity in human colon tumours and a xenograft mouse model. Our finding links the anti-neoplastic activity of FoxO1 and the process of autophagy.

语种英语
WOS记录号WOS:000279374400010
引用统计
被引频次:264[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53888
专题北京大学第二临床医学院
北京大学基础医学院
作者单位1.Tsinghua Univ, Dept Biol Sci, Beijing 100084, Peoples R China
2.Peking Univ, Beijing 00142, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Surg, Affiliated Hosp 2, Beijing 100044, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Sch Oncol, Beijing 00142, Peoples R China
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Zhao, Ying,Yang, Jing,Liao, Wenjuan,et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity[J]. NATURE CELL BIOLOGY,2010,12(7):665-U88.
APA Zhao, Ying.,Yang, Jing.,Liao, Wenjuan.,Liu, Xiangyu.,Zhang, Hui.,...&Zhu, Wei-Guo.(2010).Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.NATURE CELL BIOLOGY,12(7),665-U88.
MLA Zhao, Ying,et al."Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity".NATURE CELL BIOLOGY 12.7(2010):665-U88.
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