IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway
Zeng, Q. J.1; Wang, L. N.1; Shu, G.1; Wang, S. B.1; Zhu, X. T.1; Gao, P.1; Xi, Q. Y.1; Zhang, Y. L.1; Zhang, Z. Q.2; Jiang, Q. Y.1
关键词Qm7 Myoblast Decorin Myostatin Cell Proliferation Smad3
刊名POULTRY SCIENCE
2014
DOI10.3382/ps.2013-03300
93期:1页:138-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Agriculture, Dairy & Animal Science
研究领域[WOS]Agriculture
关键词[WOS]GROWTH-FACTOR-BETA ; IN-VIVO ; DEVELOPMENTAL EXPRESSION ; TRANSCRIPTION FACTORS ; CONNECTIVE-TISSUE ; MUSCLE GROWTH ; DIFFERENTIATION ; MECHANISM ; MYOGENESIS ; CELLS
英文摘要

Decorin, a small leucine-rich proteoglycan as a component of the extracellular matrix, plays an important role in the skeletal muscle development. It has been reported that decorin promoted proliferation and differentiation of muscle cells by restraining myostatin activity in rodents. However, the effects and mechanisms of decorin on avian myoblast proliferation are not understood clearly. Thus, in our research, decorin overexpressing and knocking-down quail myoblast-7 (QM7) myoblasts were established to explore the effects of decorin on avian myoblast proliferation by flow cytometry. The results showed that overexpression of decorin enhanced the proliferation of QM7 myoblasts, which was accompanied by the upregulation of follistatin and primary muscle regulatory factors (i.e., myogenic factor 5, myogenic factor 1, myogenin), and downregulation of myostatin expression, as well as the decreased phosphorylation level of SMAD family member 3 (Smad3). In line with expectations, decorin RNAi displayed an opposite effect on the proliferation and gene expression pattern of QM7 cells. In conclusion, our in vitro studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation.

语种英语
WOS记录号WOS:000334041800019
项目编号31101780 ; 2009CB941601 ; 20114404120001
资助机构National Natural Science Foundation for the Young Scholars of China (Beijing) ; National Basic Research Program of China-the 973 Program (Beijing) ; Research Fund for the Doctoral Program of Higher Education (Beijing)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53892
专题北京大学基础医学院_细胞生物学系
作者单位1.South China Agr Univ, Coll Anim Sci, ALLTECH SCAU Anim Nutr Control Res Alliance, Guangzhou 510642, Guangdong, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Cell Biol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
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GB/T 7714
Zeng, Q. J.,Wang, L. N.,Shu, G.,et al. Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway[J]. POULTRY SCIENCE,2014,93(1):138-146.
APA Zeng, Q. J..,Wang, L. N..,Shu, G..,Wang, S. B..,Zhu, X. T..,...&Jiang, Q. Y..(2014).Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway.POULTRY SCIENCE,93(1),138-146.
MLA Zeng, Q. J.,et al."Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway".POULTRY SCIENCE 93.1(2014):138-146.
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