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学科主题: 临床医学
题名:
Dysfunction of myocardial taurine transport and effect of taurine supplement in rats with isoproterenol-induced myocardial injury
作者: Shi, YR; Bu, DF; Qi, YF; Gao, L; Jiang, HF; Pang, YZ; Tang, CS; Du, JB
关键词: isoproterenol ; myocardium ; taurine ; transportation ; cysteine proteinases ; messenger RNA
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-10-01
卷: 23, 期:10, 页:910-918
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CYSTEINE SULFINATE DECARBOXYLASE ; MESSENGER-RNA ; EXPRESSION ; ENZYMES ; KIDNEY
英文摘要:

AIM: To study the alterations of myocardial taurine transport function, taurine transporter (TAUT), and cysteine sulfinate decarboxylase (CSD) mRNA as well as effect of exogenous taurine in rats with isoproterenol (ISO)-induced cardiomegaly. METHODS: [H-3]-Taurine uptake and release on myocardium were determined. Binding sites of [H-3]-taurine for myocardial sarcolemma were measured. TAUT and CSD mRNA levels were assayed using competitive quantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS: ISO group as compared with control group, myocardial taurine uptake markedly reduced, taurine release obviously increased; B-max value of [H-3]-taurine binding on cardiac sarcolemma reduced by 42 % (P<0.05); TAUT and CSD mRNA levels decreased by 40 % and 38 % (P<0.05), respectively. ISO+taurine group as compared with ISO-treated group, the amounts of taurine uptake and TAUT mRNA returned to normal; taurine release reduced; B-max increased by 92 % (P<0.01), and CSD mRNA content augmented by 23 % (P<0.05). There were no statistical differences of K, values among the four groups (P>0.05). CONCLUSION: The data indicate that the failure to generate sufficient TAUT on myocardial sarcolemma may be the fundamental abnormality in ISO-induced cardiac injury. The mechanism by which administration of taurine considerably improves ISO-induced cardiac damage is probably to increase the expression of TAUT gene and recover taurine transport function.

语种: 英语
WOS记录号: WOS:000178631100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53894
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Shi, YR,Bu, DF,Qi, YF,et al. Dysfunction of myocardial taurine transport and effect of taurine supplement in rats with isoproterenol-induced myocardial injury[J]. ACTA PHARMACOLOGICA SINICA,2002,23(10):910-918.
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