IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB
Wang, Rui; Li, Ying-Bo; Li, Yu-Hua; Xu, Ying; Wu, Hong-li; Li, Xue-Jun1
关键词Curcumin Bdnf Trkb Glutamate Excitotoxicity Neuroprotection Cerebral Cortical Neurons
刊名BRAIN RESEARCH
2008-05-19
DOI10.1016/j.brainres.2008.01.104
1210页:84-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]FACTOR BDNF ; HIPPOCAMPAL-NEURONS ; DEPRESSED-PATIENTS ; MOOD STABILIZERS ; OXIDATIVE STRESS ; MESSENGER-RNA ; UNITED-STATES ; EXPRESSION ; SURVIVAL ; BEHAVIOR
英文摘要

Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are still obscure. In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression. Exposure of rat cortical neurons to 10 mu M glutamate for 24 h caused a significant decrease in BDNF level, accompanied with reduced cell viability and enhanced cell apoptosis. Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner. However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin. In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a. Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000256507200010
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53895
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Wang, Rui,Li, Ying-Bo,Li, Yu-Hua,et al. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB[J]. BRAIN RESEARCH,2008,1210:84-91.
APA Wang, Rui,Li, Ying-Bo,Li, Yu-Hua,Xu, Ying,Wu, Hong-li,&Li, Xue-Jun.(2008).Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.BRAIN RESEARCH,1210,84-91.
MLA Wang, Rui,et al."Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB".BRAIN RESEARCH 1210(2008):84-91.
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