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学科主题基础医学
Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain
Xing, Guo-Gang; Liu, Feng-Yu; Qu, Xiao-Xiu; Han, Ji-Sheng; Wan, You
关键词Neuropathic Pain Long-term Potentiation Long-term Depression Opioid Nmda Receptor Electroacupuncture Spinal Dorsal Horn Electrophysiology
刊名EXPERIMENTAL NEUROLOGY
2007-12-01
DOI10.1016/j.expneurol.2007.09.004
208期:2页:323-332
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]FIBER-EVOKED POTENTIALS ; AFFERENT-INDUCED EXCITATION ; LOW-FREQUENCY STIMULATION ; PERIPHERAL-NERVE INJURY ; FIELD POTENTIALS ; ELECTRICAL-STIMULATION ; MECHANICAL ALLODYNIA ; SCIATIC-NERVE ; SEROTONIN TRANSPORTER ; LASTING POTENTIATION
英文摘要

Our previous study has reported that electroacupuncture (EA) at low frequency of 2 Hz had greater and more prolonged analgesic effects on mechanical allodynia and thermal hyperalgesia than that EA at high frequency of 100 Hz in rats with neuropathic pain. However, how EA at different frequencies produces distinct analgesic effects on neuropathic pain is unclear. Neuronal plastic changes in spinal cord might contribute to the development and maintenance of neuropathic pain. In the present study, we investigated changes of spinal synaptic plasticity in the development of neuropathic pain and its modulation by EA in rats with neuropathic pain. Field potentials of spinal dorsal horn neurons were recorded extracellularly in sham-operated rats and in rats with spinal nerve ligation (SNL). We found for the first time that the threshold for inducing long-term potentiation (LTP) of C-fiber-evoked potentials in dorsal horn was significantly lower in SNL rats than that in sham-operated rats. The threshold for evoking the C-fiber-evoked field potentials was also significantly lower, and the amplitude of the field potentials was higher in SNL rats as compared with those in the control rats. EA at low frequency of 2 Hz applied on acupoints ST 36 and SP 6, which was effective in treatment of neuropathic pain, induced long-term depression (LTD) of the C-fiber-evoked potentials in SNL rats. This effect could be blocked by N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 and by opioid receptor antagonist naloxone. In contrast, EA at high frequency of 100 Hz, which was not effective in treatment of neuropathic pain, induced LTP in SNL rats but LTD in sham-operated rats. Unlike the 2 Hz EA-induced LTD in SNL rats, the 100 Hz EA-induced LTD in sham-operated rats was dependent on the endogenous GABAergic and serotonergic inhibitory system. Results from our present study suggest that (1) hyperexcitability in the spinal nociceptive synaptic transmission may occur after nerve injury, which may contribute to the development of neuropathic pain; (2) EA at low or high frequency has a different effect on modulating spinal synaptic plasticities in rats with neuropathic pain. The different modulation on spinal LTD or LTP by low- or high-frequency EA may be a potential mechanism of different analgesic effects of EA on neuropathic pain. LTD of synaptic strength in the spinal dorsal horn in SNL rats may contribute to the long-lasting analgesic effects of EA at 2 Hz. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000251666000018
引用统计
被引频次:74[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53898
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位Peking Univ, Key Lab Neurosci Minist Educ & Publ Hlth, Dept Neurobiol, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Xing, Guo-Gang,Liu, Feng-Yu,Qu, Xiao-Xiu,et al. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain[J]. EXPERIMENTAL NEUROLOGY,2007,208(2):323-332.
APA Xing, Guo-Gang,Liu, Feng-Yu,Qu, Xiao-Xiu,Han, Ji-Sheng,&Wan, You.(2007).Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain.EXPERIMENTAL NEUROLOGY,208(2),323-332.
MLA Xing, Guo-Gang,et al."Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain".EXPERIMENTAL NEUROLOGY 208.2(2007):323-332.
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