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学科主题: 临床医学
题名:
A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia
作者: Gao, Lei; Zhu, Yan; Lyu, Yuan; Hao, Feng-Lan; Zhang, Pu; Wei, Min-Ji
关键词: Cefazedone ; Community-acquired Pneumonia ; Pharmacodynamic ; Pharmacokinetic
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-05-05
DOI: 10.4103/0366-6999.156086
卷: 128, 期:9, 页:1160-1164
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BETA-LACTAM ANTIBIOTICS ; PROPHYLAXIS ; MICE
英文摘要:

Background: As a time-dependent antibiotic, the time of cefazedone concentration exceeds the minimum inhibitory concentration (MIC) is the key pharmacokinetic-pharmacodynamic (PK-PD) variable associated with the killing of pathogens. The purpose of the study was to evaluate the clinical regimen rationality of intravenous cefazedone sodium in the treatment of community-acquired pneumonia (CAP) by PK/PD study.

Methods: Ten patients with mild to moderate CAP were enrolled to receive intravenous cefazedone sodium (2 g q12 h) for 7-14 days. Blood samples were collected in any day during day 5-7. Sputum specimens were collected before treatment for bacteria isolated, and susceptibility to cefazedone determined. PK-PD analysis was performed using the noncompartmental analysis of Phoenix WinNolin software (version 6.1, Pharsight Corporation, CA, USA). The maximal time above MIC (T > MIC) was calculated, and its correlation with clinical efficacy was analyzed.

Results: All 10 patients completed the study and 8 of them were cured. Six strains were isolated from patients before treatment (one for each patient) and all susceptible to cefazedone. Five patients of six in culture positive group were cured. All pathogens were cleared at the end of therapy. The MICs were between 0.25 and 1 mg/L. The main PK parameters were C max 175.22 36.28 mg/L; T1/2 1.52 0.23 h; AUC (0-) 280.51 68.17 mg?L (-1)?h (-1) ; CL 7.37 1.84 L/h; Vd 16.06 4.42 L. The average T > MIC was 55.45 8.12%.

Conclusions: Intravenous injection of cefazodone sodium with 2 g q12 h dosage regimen is used in the treatment of CAP caused by sensitive bacteria, either T > MIC or clinical efficacy shows that such dosing regimen is reasonable.

语种: 英语
WOS记录号: WOS:000354186800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53899
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China

Recommended Citation:
Gao, Lei,Zhu, Yan,Lyu, Yuan,et al. A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia[J]. CHINESE MEDICAL JOURNAL,2015,128(9):1160-1164.
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