IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
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A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia
Gao, Lei; Zhu, Yan; Lyu, Yuan; Hao, Feng-Lan; Zhang, Pu; Wei, Min-Ji
关键词Cefazedone Community-acquired Pneumonia Pharmacodynamic Pharmacokinetic
刊名CHINESE MEDICAL JOURNAL
2015-05-05
DOI10.4103/0366-6999.156086
128期:9页:1160-1164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]BETA-LACTAM ANTIBIOTICS ; PROPHYLAXIS ; MICE
英文摘要

Background: As a time-dependent antibiotic, the time of cefazedone concentration exceeds the minimum inhibitory concentration (MIC) is the key pharmacokinetic-pharmacodynamic (PK-PD) variable associated with the killing of pathogens. The purpose of the study was to evaluate the clinical regimen rationality of intravenous cefazedone sodium in the treatment of community-acquired pneumonia (CAP) by PK/PD study.

Methods: Ten patients with mild to moderate CAP were enrolled to receive intravenous cefazedone sodium (2 g q12 h) for 7-14 days. Blood samples were collected in any day during day 5-7. Sputum specimens were collected before treatment for bacteria isolated, and susceptibility to cefazedone determined. PK-PD analysis was performed using the noncompartmental analysis of Phoenix WinNolin software (version 6.1, Pharsight Corporation, CA, USA). The maximal time above MIC (T > MIC) was calculated, and its correlation with clinical efficacy was analyzed.

Results: All 10 patients completed the study and 8 of them were cured. Six strains were isolated from patients before treatment (one for each patient) and all susceptible to cefazedone. Five patients of six in culture positive group were cured. All pathogens were cleared at the end of therapy. The MICs were between 0.25 and 1 mg/L. The main PK parameters were C max 175.22 36.28 mg/L; T1/2 1.52 0.23 h; AUC (0-) 280.51 68.17 mg?L (-1)?h (-1) ; CL 7.37 1.84 L/h; Vd 16.06 4.42 L. The average T > MIC was 55.45 8.12%.

Conclusions: Intravenous injection of cefazodone sodium with 2 g q12 h dosage regimen is used in the treatment of CAP caused by sensitive bacteria, either T > MIC or clinical efficacy shows that such dosing regimen is reasonable.

语种英语
WOS记录号WOS:000354186800005
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53899
专题北京大学第一临床医学院_临床药理研究所
作者单位Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Gao, Lei,Zhu, Yan,Lyu, Yuan,et al. A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia[J]. CHINESE MEDICAL JOURNAL,2015,128(9):1160-1164.
APA Gao, Lei,Zhu, Yan,Lyu, Yuan,Hao, Feng-Lan,Zhang, Pu,&Wei, Min-Ji.(2015).A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia.CHINESE MEDICAL JOURNAL,128(9),1160-1164.
MLA Gao, Lei,et al."A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia".CHINESE MEDICAL JOURNAL 128.9(2015):1160-1164.
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