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Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat
Wang, Feng1,3; Xue, Jinfeng1,3; Wang, Danjun2; Wang, Xianyou1; Lu, Shukun2; Tan, Mengqun1,3
关键词Atherosclerosis Paraoxonase-1 Endothelial Progenitor Cell Adeno-associated Virus Gene Therapy
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2010-11-01
33期:11页:1806-1813
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]LIPOPROTEIN-LIPASE DEFICIENCY ; LOW-DENSITY-LIPOPROTEIN ; APOLIPOPROTEIN-E ; BENEFICIAL MUTATION ; ARTERIAL INJURY ; UP-REGULATION ; OXIDIZED LDL ; VECTORS ; OVEREXPRESSION ; DYSFUNCTION
英文摘要

Endothelial dysfunction/loss is a key event in the development of vascular diseases, including native atherosclerosis (AS). Recent studies have shown that endothelial progenitor cells (EPCs) have the ability to repair endothelial cells that have been lost or damaged following AS. As a result, the therapy of transplanting EPCs is a promising option for the treatment of AS. However, the therapeutic effect on AS with only EPCs transplantation has not been satisfactory. The upregulation of those genes, which prevent the progress of AS in EPCs, is a novel therapeutic strategy for AS. Because it can reduce macrophage foam cell formation and protect endothelial cells from the oxidation of low-density lipoprotein (ox-LDL), paraoxonase-1 (PON1) gene is a candidate for gene therapy in AS. In this study, a recombinant adeno-associated virus (rAAV) vector carrying the human paraoxonase-1 (hPON1) gene (rAAV-PON1) was constructed, and endothelial progenitor cells (EPCs) transfected with rAAV-PON1 were transplanted into the atherosclerosis model of Sprague-Dawley rats (SD rats). The results of doppler ultrasound and histological analysis showed that the group transplanted with the hPON1 gene-transfected EPCs was superior to the group transplanted only with the EPCs and was also better than the group with h PON1 gene injection alone. The results indicated that rAAV-mediated hPON1 gene-transfected EPCs is a potentially valuable new tool in the treatment of atherosclerosis.

语种英语
WOS记录号WOS:000283522400009
资助机构Shenzhen Institute of Xiangya Biomedicine
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53905
专题北京大学深圳医院
北京大学临床肿瘤学院_核医学科
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen 518049, Peoples R China
2.Shenzhen Inst Xiangya Biomed, Shenzhen 518057, Peoples R China
3.Cent S Univ, Expt Hematol Lab, Dept Physiol, Xiang Ya Sch Med, Changsha 410008, Hunan, Peoples R China
推荐引用方式
GB/T 7714
Wang, Feng,Xue, Jinfeng,Wang, Danjun,et al. Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(11):1806-1813.
APA Wang, Feng,Xue, Jinfeng,Wang, Danjun,Wang, Xianyou,Lu, Shukun,&Tan, Mengqun.(2010).Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat.BIOLOGICAL & PHARMACEUTICAL BULLETIN,33(11),1806-1813.
MLA Wang, Feng,et al."Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat".BIOLOGICAL & PHARMACEUTICAL BULLETIN 33.11(2010):1806-1813.
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