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学科主题: 临床医学
题名:
Increased plasma sVCAM-1 is associated with severity in IgA nephropathy
作者: Zhu, Li; Shi, Sufang; Liu, Lijun; Lv, Jicheng; Zhang, Hong1
关键词: sVCAM-1 ; IgA nephropathy ; Vascular injury
刊名: BMC NEPHROLOGY
发表日期: 2013-01-22
DOI: 10.1186/1471-2369-14-21
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SOLUBLE ADHESION MOLECULES ; TERM-FOLLOW-UP ; ABERRANTLY GLYCOSYLATED IGA1 ; CHRONIC KIDNEY-DISEASE ; NATURAL-HISTORY ; CARDIOVASCULAR-DISEASE ; TNF-ALPHA ; GLOMERULONEPHRITIS ; SELECTIN ; COMMUNICATION
英文摘要:

Background: A considerable proportion of IgAN patients present with histological vasculitic/crescentic lesions in glomeruli, indicating activation of vascular inflammation. Using sVCAM-1, a well-proven marker for endothelial injury under inflammatory processes, we investigated vascular injury and its association with clinical and pathological manifestations in IgAN patients.

Methods: In this study, 327 biopsy-proven IgAN patients and 55 healthy controls were enrolled. The Oxford classification and two variables, Active Crescentic Lesion Percentage (ACLP) and Chronic Glomerular Lesion Percentage (CGLP), were used for evaluating pathological lesions. Human Umbilical Vein Endothelial Cells were treated with 25-400 ug/ml IgA1. sVCAM-1 in plasma and culture supernatant were measured by ELISA.

Results: Plasma sVCAM-1 in IgAN patients was significantly higher than healthy controls. In patients with IgAN, plasma sVCAM-1 was significantly correlated with eGFR, 24h urine protein excretion, tubular atrophy/interstitial fibrosis lesion and ACLP, but not CGLP. Meanwhile, compared to healthy volunteers, IgA1 from IgAN patients showed a tendency to increase the HUVECs supernatant sVCAM-1 expression. And IgA1 induced the sVCAM-1 increasing from HUVECs in time-and dose-dependent manner.

Conclusions: We found increased plasma sVCAM-1 in IgAN patients and its association with severe clinical and pathological manifestations, which might be partly resulted from effect of IgA1 to endothelial cells.

语种: 英语
所属项目编号: 81000297 ; PUCRP201102 ; 81021004
项目资助者: National Science Foundation for Youths of China ; Peking University Clinical Research Program ; National Natural Science Foundation for Innovative Research Groups of China
WOS记录号: WOS:000314266500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53906
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Zhu, Li,Shi, Sufang,Liu, Lijun,et al. Increased plasma sVCAM-1 is associated with severity in IgA nephropathy[J]. BMC NEPHROLOGY,2013,14.
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