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学科主题: 基础医学
题名:
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors
作者: Wang, Rui; Xu, Ying; Wu, Hong-Li; Li, Ying-Bo; Li, Yu-Hua; Guo, Ha-Bin; Li, Xue-Jun1
关键词: curcumin ; depression ; antidepressant ; forced swimming test ; 5-HT1A/1B receptors ; 5-HT2A/2C receptors
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2008-01-06
DOI: 10.1016/j.ejphar.2007.08.045
卷: 578, 期:1, 页:43-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: IN-VIVO MICRODIALYSIS ; ALTERNATIVE THERAPIES ; MOUSE ; MICE ; DEPRESSION ; ANTAGONISTS ; SEROTONIN ; MEDIATION ; ANXIETY ; 5-HYDROXYTRYPTAMINE(1A)
英文摘要:

Curcuma longa is a main constituent of many traditional Chinese medicines, such as Xiaoyao-san, used to manage mental disorders effectively. Curcumin is a major active component of C. longa and its antidepressant-like effect has been previously demonstrated in the forced swimming test. The purpose of this study was to explore the possible contribution of serotonin (5-HT) receptors in the behavioral effects induced by curcumin in this animal model of depression. 5-HT was depleted by the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA, 100 mg/kg, i.p.) prior to the administration of curcumin, and the consequent results showed that PCPA blocked the anti-immobility effect of curcumin in forced swimming test, suggesting the involvement of the scrotonergic system. Moreover, pre-treatment of pindolol (10 mg/kg, i.p., a beta-adrenoceptors blocker/5-HT1A/1B receptor antagonist), 4-(2′-methoxy-phenyl)-1-[2-(n-2 ′′-pyridinyl)-p-iodobenzamino-]ethyl-piperazine (p-MPPI, 1 mg/kg, s.c., a selective 5-HT1A receptor antagonist), or 1-(2-(I-pyrrolyl)-phenoxy)-3-isopropylamino-2-propanol (isamoltane, 2.5 mg/kg, i.p., a 5-HT1B receptor antagonist) was found to prevent the effect of curcumin (10 mg/kg) in forced swimming test. On the other hand, a sub-effective dose of curcumin (2.5 mg/kg, p.o.) produced a synergistic effect when given jointly with (+)-8-hydroxy-2-(di-n-propylamino)tetralin, (8-OH-DPAT, 1 mg/kg, i.p., a 5-HT1A receptor agonist), anpirtoline (0.25 mg/kg, i.p., a 5-HT1B receptor agonist) or ritanserin (4 mg/kg, i.p., a 5-HT2A/2C receptor antagonist), but not with ketanserin (5 mg/kg, i.p., a 5-HT2A/2C receptor antagonist with higher affinity to 5-HT2A receptor) or R(-)-1-(2,5dimethoxy-4-iodophenyl)-2-aminopropane (DOI, 1 mg/kg, i.p., a 5-HT2A receptor agonist). Taken together, these results indicate that the antidepressant-like effect of curcumin in the forced swimming test is related to serotonergic system and may be mediated by, at least in part, an interaction with 5-HT1A/1B and 5-HT c receptors. (c) 2007 Published by Elsevier B.V.

语种: 英语
WOS记录号: WOS:000252982900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53910
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Rui,Xu, Ying,Wu, Hong-Li,et al. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,578(1):43-50.
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