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学科主题基础医学
The nascent polypeptide-associated complex is essential for autophagic flux
Guo, Bin2; Huang, Jie1,2; Wu, Wenxian3; Feng, Du3; Wang, Xiaochen4; Chen, Yingyu1; Zhang, Hong2
关键词NAC autophagy lysosome C. elegans
刊名AUTOPHAGY
2014-10-01
DOI10.4161/auto.29638
10期:10页:1738-1748
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]C. ELEGANS ; BETA-NAC ; PROTEIN ; MATURATION ; CLEARANCE ; HOMOLOG ; DEGRADATION ; PROGRESSION ; DROSOPHILA ; MACHINERY
英文摘要

The ribosome-associated nascent polypeptide-associated complex (NAC) is involved in multiple cotranslational processes, including protein transport into the ER and mitochondria, and also acts as a chaperone to assist protein folding. Here we demonstrated that NAC is also essential for autophagic degradation of a variety of protein aggregates in C. elegans. Loss of function of NAC impairs lysosome function, resulting in accumulation of autophagic substrates in enlarged autolysosomes. Knockdown of mammalian NAC also causes accumulation of nondegradative autolysosomes. Our study revealed that NAC plays an evolutionarily conserved role in the autophagy pathway and thus in maintaining protein homeostasis under physiological conditions.

语种英语
WOS记录号WOS:000345704900006
项目编号2013CB910100 ; 2011CB910100
资助机构National Basic Research Program of China ; International Early Career Scientist grant from the Howard Hughes Medical Institute
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53913
专题北京大学基础医学院_免疫学系
北京大学第二临床医学院_急诊科
作者单位1.Natl Inst Biol Sci, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Biophys, State Key Lab Biomacromol, Beijing 100080, Peoples R China
4.Guangdong Med Coll, Affiliated Hosp, Inst Neurol, Key Lab Age Associated Cardiac Cerebral Vasc Dis, Zhanjiang, Peoples R China
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GB/T 7714
Guo, Bin,Huang, Jie,Wu, Wenxian,et al. The nascent polypeptide-associated complex is essential for autophagic flux[J]. AUTOPHAGY,2014,10(10):1738-1748.
APA Guo, Bin.,Huang, Jie.,Wu, Wenxian.,Feng, Du.,Wang, Xiaochen.,...&Zhang, Hong.(2014).The nascent polypeptide-associated complex is essential for autophagic flux.AUTOPHAGY,10(10),1738-1748.
MLA Guo, Bin,et al."The nascent polypeptide-associated complex is essential for autophagic flux".AUTOPHAGY 10.10(2014):1738-1748.
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