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学科主题: 基础医学
题名:
The nascent polypeptide-associated complex is essential for autophagic flux
作者: Guo, Bin2; Huang, Jie1,2; Wu, Wenxian3; Feng, Du3; Wang, Xiaochen4; Chen, Yingyu1; Zhang, Hong2
关键词: NAC ; autophagy ; lysosome ; C. elegans
刊名: AUTOPHAGY
发表日期: 2014-10-01
DOI: 10.4161/auto.29638
卷: 10, 期:10, 页:1738-1748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: C. ELEGANS ; BETA-NAC ; PROTEIN ; MATURATION ; CLEARANCE ; HOMOLOG ; DEGRADATION ; PROGRESSION ; DROSOPHILA ; MACHINERY
英文摘要:

The ribosome-associated nascent polypeptide-associated complex (NAC) is involved in multiple cotranslational processes, including protein transport into the ER and mitochondria, and also acts as a chaperone to assist protein folding. Here we demonstrated that NAC is also essential for autophagic degradation of a variety of protein aggregates in C. elegans. Loss of function of NAC impairs lysosome function, resulting in accumulation of autophagic substrates in enlarged autolysosomes. Knockdown of mammalian NAC also causes accumulation of nondegradative autolysosomes. Our study revealed that NAC plays an evolutionarily conserved role in the autophagy pathway and thus in maintaining protein homeostasis under physiological conditions.

语种: 英语
所属项目编号: 2013CB910100 ; 2011CB910100
项目资助者: National Basic Research Program of China ; International Early Career Scientist grant from the Howard Hughes Medical Institute
WOS记录号: WOS:000345704900006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53913
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Natl Inst Biol Sci, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Biophys, State Key Lab Biomacromol, Beijing 100080, Peoples R China
4.Guangdong Med Coll, Affiliated Hosp, Inst Neurol, Key Lab Age Associated Cardiac Cerebral Vasc Dis, Zhanjiang, Peoples R China

Recommended Citation:
Guo, Bin,Huang, Jie,Wu, Wenxian,et al. The nascent polypeptide-associated complex is essential for autophagic flux[J]. AUTOPHAGY,2014,10(10):1738-1748.
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