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学科主题临床医学
Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances
Mo, X-D1; Zhao, X-Y1; Liu, D-H1; Chen, Y-H1; Xu, L-P1; Zhang, X-H1; Chen, H.1; Han, W.1; Wang, Y.1; Wang, F-R1; Wang, J-Z1; Liu, K-Y1; Huang, X-J1,2
刊名BONE MARROW TRANSPLANTATION
2014-08-01
DOI10.1038/bmt.2014.109
49期:8页:1070-1075
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; LEUKEMIA ; DEPLETION ; CHILDREN ; OUTCOMES ; GRAFT
英文摘要

This study aimed to compare the therapeutic effects of single umbilical cord blood transplantation (UCBT) and unmanipulated haploidentical hematopoietic SCT (haplo-HSCT) in childhood hematologic malignances. We enrolled 410 consecutive children who received either single UCBT (n = 37) or haplo-HSCT from a family donor (n = 373) during the same time period. For each UCBT recipient, three recipients matched for year of HSCT, underlying diseases, disease status and the length of follow-up were randomly selected from the haplo-HSCT cohort. Hematopoietic recovery was significantly faster in haplo-HSCT recipients than in UCBT recipients. The incidence of chronic GVHD was significantly higher in haplo-HSCT recipients. The incidence of CMV-related interstitial pneumonia was higher in UCBT recipients. The haplo-HSCT recipients had better 1-year OS (73.0% vs 56.8%, P = 0.048), lower 1-year non-relapse mortality (NRM, 18.0% vs 35.1%, P = 0.026) and lower 2-year NRM rates (19.9% vs 35.1%, P = 0.044). The relapse- and disease-free survival rates did not differ significantly between the groups. Our results showed that compared with UCBT, unmanipulated haplo-HSCT can improve the outcomes of children with hematologic malignances.

语种英语
WOS记录号WOS:000341283000013
项目编号Z111107067311070 ; 81230013
资助机构Beijing Municipal Science and Technology Program ; Key Program of National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53915
专题北京大学第二临床医学院_血液科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Mo, X-D,Zhao, X-Y,Liu, D-H,et al. Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances[J]. BONE MARROW TRANSPLANTATION,2014,49(8):1070-1075.
APA Mo, X-D.,Zhao, X-Y.,Liu, D-H.,Chen, Y-H.,Xu, L-P.,...&Huang, X-J.(2014).Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances.BONE MARROW TRANSPLANTATION,49(8),1070-1075.
MLA Mo, X-D,et al."Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances".BONE MARROW TRANSPLANTATION 49.8(2014):1070-1075.
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