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学科主题: 基础医学
题名:
Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells
作者: Wang, K; Wang, JJ; Wang, Y; He, QH; Wang, X; Wang, XM
关键词: adult neural progenitor cells ; neurospheres ; Parkinson&prime ; s disease ; growth factors ; striatum ; substantia nigra
刊名: NEUROSCIENCE LETTERS
发表日期: 2004-07-08
DOI: 10.1016/j.neulet.2004.04.086
卷: 364, 期:3, 页:154-158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; BRAIN ; NEUROGENESIS ; INDUCTION ; NEOCORTEX ; REGIONS ; NEURONS ; MICE ; CNS
英文摘要:

This study investigated the proliferation and differentiation of adult neural progenitor cells (aNPCs) derived from the striatum and substantia nigra (SN) of parkinsonian rats. We found that aNPCs isolated from the two areas of parkinsonian rats readily formed nestin-enriched neurospheres in vitro and exhibited an ability to differentiate into either neurons or astrocytes. Injection of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) into the striatum of parkinsonian rats prior to the harvesting striatal aNPCs significantly increased the neurosphere formation rate and multiple differentiation capacity of these aNPCs when cultured in vitro. These data suggest that striatal and nigral adult NPCs in parkinsonian rats retain the abilities of proliferation and differentiation in vitro. In addition, exogenously applied growth factors could up-regulate the developmental potential of aNPCs. We conclude that our data supports the notion that endogenous cell replacement therapies may be useful for the future treatment of Parkinson′s disease (PD). (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000222289700006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53917
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Capital Univ Med Sci, Dept Physiol, Beijing 100054, Peoples R China

Recommended Citation:
Wang, K,Wang, JJ,Wang, Y,et al. Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells[J]. NEUROSCIENCE LETTERS,2004,364(3):154-158.
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