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Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children
Liu, Daihong; Huang, Xiaojun; Liu, Kaiyan; Xu, Lanping; Chen, Huan; Han, Wei; Chen, Yuhong; Zhang, Xiaohui; Jiang, Qian
关键词Hematopoietic Stem Cell Transplantation Haploidentical Hematological Malignancies Children
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2008-04-01
DOI10.1016/j.bbmt.2008.02.007
14期:4页:469-477
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; VERSUS-HOST-DISEASE ; ONCOLOGY-GROUP ; THERAPY ; BLOOD ; OUTCOMES ; CHEMOTHERAPY ; REMISSION
英文摘要

To investigate the efficacy and safety of haploidentical (from family member donors) hematopoietic stem cell transplantation (HSCT) for children. 42 children under 14 yrs old with hematological malignancies underwent haploidentical HSCT. Outcomes were analyzed. Thirty-three children were classified as high-risk candidates. Of 42 patient/donor pairs, 4 (9.5%) were mismatched in 2 HLA loci, 15 (35.7%) in 3 loci, and 23 (54.8%) in 4 loci. Follow-ups were performed for a median of 1110 (449-1959) days after transplantation. All patients achieved stable engraftments. The cumulative incidence of acute graft-versus-host disease (aGVHD) of grade 2-4 was 57.2%, and that of grade 3-4 was 13.8%. The cumulative incidence of chronic graft-versus-host disease (cGVHD) was 56.7% for total and 29.5% for extensive. Twenty-seven patients survived with a 3-yr probability of leukemia-free survival (LFS), 57.3 +/- 8%, 18 of them were in the high-risk group. Fifteen patients died, 4 from infection, 7 from relapse of leukemia, 2 from heart failure, one from severe aGVHD, and one from lymphoproliferative disorders. The results encourage extending haploidentical HSCT without T cell depletion treatments to children with an indication for transplantation. (c) 2008 American Society for Blood and Marrow Transplantation

语种英语
WOS记录号WOS:000254418500012
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53919
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu, Daihong,Huang, Xiaojun,Liu, Kaiyan,et al. Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2008,14(4):469-477.
APA Liu, Daihong.,Huang, Xiaojun.,Liu, Kaiyan.,Xu, Lanping.,Chen, Huan.,...&Jiang, Qian.(2008).Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,14(4),469-477.
MLA Liu, Daihong,et al."Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 14.4(2008):469-477.
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