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学科主题: 临床医学
题名:
Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children
作者: Liu, Daihong; Huang, Xiaojun; Liu, Kaiyan; Xu, Lanping; Chen, Huan; Han, Wei; Chen, Yuhong; Zhang, Xiaohui; Jiang, Qian
关键词: hematopoietic stem cell transplantation ; haploidentical ; hematological malignancies ; children
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2008-04-01
DOI: 10.1016/j.bbmt.2008.02.007
卷: 14, 期:4, 页:469-477
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; VERSUS-HOST-DISEASE ; ONCOLOGY-GROUP ; THERAPY ; BLOOD ; OUTCOMES ; CHEMOTHERAPY ; REMISSION
英文摘要:

To investigate the efficacy and safety of haploidentical (from family member donors) hematopoietic stem cell transplantation (HSCT) for children. 42 children under 14 yrs old with hematological malignancies underwent haploidentical HSCT. Outcomes were analyzed. Thirty-three children were classified as high-risk candidates. Of 42 patient/donor pairs, 4 (9.5%) were mismatched in 2 HLA loci, 15 (35.7%) in 3 loci, and 23 (54.8%) in 4 loci. Follow-ups were performed for a median of 1110 (449-1959) days after transplantation. All patients achieved stable engraftments. The cumulative incidence of acute graft-versus-host disease (aGVHD) of grade 2-4 was 57.2%, and that of grade 3-4 was 13.8%. The cumulative incidence of chronic graft-versus-host disease (cGVHD) was 56.7% for total and 29.5% for extensive. Twenty-seven patients survived with a 3-yr probability of leukemia-free survival (LFS), 57.3 +/- 8%, 18 of them were in the high-risk group. Fifteen patients died, 4 from infection, 7 from relapse of leukemia, 2 from heart failure, one from severe aGVHD, and one from lymphoproliferative disorders. The results encourage extending haploidentical HSCT without T cell depletion treatments to children with an indication for transplantation. (c) 2008 American Society for Blood and Marrow Transplantation

语种: 英语
WOS记录号: WOS:000254418500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53919
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Daihong,Huang, Xiaojun,Liu, Kaiyan,et al. Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2008,14(4):469-477.
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