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学科主题: 药学
题名:
NO inhibitory guaianolide-derived terpenoids from Artemisia argyi
作者: Wang, Shu1; Li, Jun2; Sun, Jian1; Zeng, Ke-wu1; Cui, Jing-rong1; Jiang, Yong1; Tu, Peng-fei1
关键词: Artemisia argyi ; Guaianolide-derived terpenoid ; Absolute configuration ; Nitric oxide
刊名: FITOTERAPIA
发表日期: 2013-03-01
DOI: 10.1016/j.fitote.2012.12.005
卷: 85, 页:169-175
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: FARNESYL-PROTEIN TRANSFERASE ; SESQUITERPENE LACTONES ; NITRIC-OXIDE ; DIMERIC GUAIANOLIDES ; CIRCULAR-DICHROISM ; ANTITUMOR-ACTIVITY ; CONSTITUENTS ; CHEMOSENSITIVITY ; ARTEMINOLIDE ; INFLAMMATION
英文摘要:

An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ES1MS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00 mu M. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30973629 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Natural Science Foundation of China ; National Key Technology R&amp ; D Program New Drug Innovation of China
WOS记录号: WOS:000317172000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53923
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Wang, Shu,Li, Jun,Sun, Jian,et al. NO inhibitory guaianolide-derived terpenoids from Artemisia argyi[J]. FITOTERAPIA,2013,85:169-175.
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