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NO inhibitory guaianolide-derived terpenoids from Artemisia argyi
Wang, Shu1; Li, Jun2; Sun, Jian1; Zeng, Ke-wu1; Cui, Jing-rong1; Jiang, Yong1; Tu, Peng-fei1
关键词Artemisia Argyi Guaianolide-derived Terpenoid Absolute Configuration Nitric Oxide
刊名FITOTERAPIA
2013-03-01
DOI10.1016/j.fitote.2012.12.005
85页:169-175
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]FARNESYL-PROTEIN TRANSFERASE ; SESQUITERPENE LACTONES ; NITRIC-OXIDE ; DIMERIC GUAIANOLIDES ; CIRCULAR-DICHROISM ; ANTITUMOR-ACTIVITY ; CONSTITUENTS ; CHEMOSENSITIVITY ; ARTEMINOLIDE ; INFLAMMATION
英文摘要

An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ES1MS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00 mu M. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000317172000024
项目编号30973629 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助机构National Natural Science Foundation of China ; National Key Technology R&amp ; D Program New Drug Innovation of China
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53923
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
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GB/T 7714
Wang, Shu,Li, Jun,Sun, Jian,et al. NO inhibitory guaianolide-derived terpenoids from Artemisia argyi[J]. FITOTERAPIA,2013,85:169-175.
APA Wang, Shu.,Li, Jun.,Sun, Jian.,Zeng, Ke-wu.,Cui, Jing-rong.,...&Tu, Peng-fei.(2013).NO inhibitory guaianolide-derived terpenoids from Artemisia argyi.FITOTERAPIA,85,169-175.
MLA Wang, Shu,et al."NO inhibitory guaianolide-derived terpenoids from Artemisia argyi".FITOTERAPIA 85(2013):169-175.
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