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学科主题临床医学
Alterations of the preoperative coagulation profile in patients with acute appendicitis
Li, Jianxin2; Liu, Yan3; Yin, Weihua4; Zhang, Chuanzhou2; Huang, Jinhe2; Liao, Chaoyu2; Nie, Liping2; Zhou, Yu2; Xiao, Ping1
关键词Acute Appendicitis Coagulation Factor Coagulation Screening Tests Endotoxin Leukocyte Parameters
刊名CLINICAL CHEMISTRY AND LABORATORY MEDICINE
2011-08-01
DOI10.1515/CCLM.2011.214
49期:8页:1333-1339
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]DISSEMINATED INTRAVASCULAR COAGULATION ; FACTOR PATHWAY INHIBITOR ; TISSUE FACTOR ; PERFORATED APPENDICITIS ; HUMAN ENDOTOXEMIA ; CYTOKINE LEVELS ; SEVERE SEPSIS ; FACTOR VIIA ; INFLAMMATION ; ACTIVATION
英文摘要

Background: Acute appendicitis (AA) is usually associated with a systemic inflammatory response that often leads to activation of coagulation. However, limited data about coagulation changes in AA are available.

Methods: Results of preoperative coagulation testing in 702 patients with confirmed AA and 697 patients undergoing minor elective surgery (control) during the same period were analyzed retrospectively. Coagulation activity of factors VII, IX (FVII: C, FIX: C) and the concentration of plasma endotoxin from 40 patients with AA and 15 control subjects were measured.

Results: Compared with control subjects, prothrombin time (PT), fibrinogen (Fib) and endotoxin increased (all p<0.01), FVII: C decreased (p<0.05), and thrombin time shortened (p<0.01) significantly in patients with AA, which showed trends with increasing severity of disease. Areas under the receiver operating characteristic curve of Fib for discriminating complicated appendicitis or acute perforated appendicitis from enrolled patients were larger than those for leukocyte parameters. The concentration of endotoxin correlated negatively with FVII: C (r=-0.860, p<0.001), positively with PT (0.713, <0.001), and FVII: C negatively with PT (-0.729, <0.001) in individuals that were evaluated. The change in activated partial thromboplastin time and difference in FIX: C among patients with various pathological types of appendicitis were not significant.

Conclusions: Endotoxin-induced activation of the extrinsic coagulation pathway was present in patients with AA. Fib may be useful as a potential indicator for excluding complicated appendicitis.

语种英语
WOS记录号WOS:000293561900015
项目编号200609
资助机构Health Bureau in Shenzhen City, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53926
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Gen Surg, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Patients Arch Management & Stat, Shenzhen 518036, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Li, Jianxin,Liu, Yan,Yin, Weihua,et al. Alterations of the preoperative coagulation profile in patients with acute appendicitis[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2011,49(8):1333-1339.
APA Li, Jianxin.,Liu, Yan.,Yin, Weihua.,Zhang, Chuanzhou.,Huang, Jinhe.,...&Xiao, Ping.(2011).Alterations of the preoperative coagulation profile in patients with acute appendicitis.CLINICAL CHEMISTRY AND LABORATORY MEDICINE,49(8),1333-1339.
MLA Li, Jianxin,et al."Alterations of the preoperative coagulation profile in patients with acute appendicitis".CLINICAL CHEMISTRY AND LABORATORY MEDICINE 49.8(2011):1333-1339.
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