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学科主题临床医学
Pulse wave velocity is associated with metabolic syndrome components in CAPD patients
Zhe, Xing-wei1; Zeng, Jing1; Tian, Xin-kui1; Chen, Wei1; Gu, Yue1; Cheng, Li-tao1; Chen, Hui-min1; Axelsson, Jonas2; Lindholm, Bengt2; Wang, Tao1
关键词Arterial Stiffness Chronic Kidney Disease Hypertension Dyslipidemia Cardiovascular Disease
刊名AMERICAN JOURNAL OF NEPHROLOGY
2008
DOI10.1159/000117813
28期:4页:641-646
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]PERITONEAL-DIALYSIS PATIENTS ; CHRONIC KIDNEY-DISEASE ; CORONARY-ARTERY-DISEASE ; STAGE RENAL-DISEASE ; AORTIC STIFFNESS ; CARDIOVASCULAR MORTALITY ; ALL-CAUSE ; ESSENTIAL-HYPERTENSION ; INDEPENDENT PREDICTOR ; VALVE CALCIFICATION
英文摘要

Background: Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV. Methods: Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV). Results: Patients′ MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R 2 of the model was 0.24. Conclusion: MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients. Copyright (C) 2008 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000255896200013
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53927
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
北京大学第一临床医学院_皮肤性病科
北京大学口腔医学院_综合治疗二科
作者单位1.Peking Univ, Div Nephrol, Hosp 3, Beijing 100083, Peoples R China
2.Karolinska Inst, Div Renal Med & Baxter Novum, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
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GB/T 7714
Zhe, Xing-wei,Zeng, Jing,Tian, Xin-kui,et al. Pulse wave velocity is associated with metabolic syndrome components in CAPD patients[J]. AMERICAN JOURNAL OF NEPHROLOGY,2008,28(4):641-646.
APA Zhe, Xing-wei.,Zeng, Jing.,Tian, Xin-kui.,Chen, Wei.,Gu, Yue.,...&Wang, Tao.(2008).Pulse wave velocity is associated with metabolic syndrome components in CAPD patients.AMERICAN JOURNAL OF NEPHROLOGY,28(4),641-646.
MLA Zhe, Xing-wei,et al."Pulse wave velocity is associated with metabolic syndrome components in CAPD patients".AMERICAN JOURNAL OF NEPHROLOGY 28.4(2008):641-646.
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