IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Significance of Antibodies Against the Native Ribosomal P Protein Complex and Recombinant P0, P1, and P2 Proteins in the Diagnosis of Chinese Patients with Systemic Lupus Erythematosus
Li, Jing1; Shen, Ying2; He, Jing1; Jia, Rulin1; Wang, Xiujie2; Chen, Xiaosan2; Wang, Dahai2; Han, Lei1; Zhu, Lei1; Chi, Xiaofeng2; Saschenbrecker, Sandra2; Daehnrich, Cornelia2; Stoecker, Winfried2; Schlumberger, Wolfgang2; Li, Zhan-Guo1
关键词Antiribosomal p Protein Antibody Autoimmunity Elisa Rib-p Sle
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2013-03-01
DOI10.1002/jcla.21543
27期:2页:87-95
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
资助者National High Technology Research and Development Program of China (863 Program) ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; Beijing Municipal Natural Science Foundation
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]PSYCHIATRIC MANIFESTATIONS ; NEUROPSYCHIATRIC EVENTS ; REVISED CRITERIA ; COMMON EPITOPE ; HIGH-FREQUENCY ; AUTOANTIBODIES ; DISEASE ; ASSOCIATION ; CLASSIFICATION ; POPULATIONS
英文摘要

BackgroundThis study aimed to evaluate autoantibodies against the native ribosomal P complex (anti-Rib-P-C) and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for their prevalence, diagnostic relevance and clinical associations in a Chinese cohort with systemic lupus erythematosus (SLE).

MethodsAnti-Rib-P, anti-dsDNA and anti-Smith antigen (Sm) antibodies were analyzed in sera from 198 patients with SLE, 33 with rheumatoid arthritis, 61 with Sjogren′s syndrome and 70 healthy individuals by means of ELISA.

ResultsAntibody prevalences were 29.8% (anti-Rib-P-C), 33.3% (anti-Rib-P0), 42.9% (anti-Rib-P1) and 34.3% (anti-Rib-P2), at a specificity of 99%. Among SLE patients lacking anti-dsDNA and anti-Sm, 27.8% showed positive for at least one of the investigated anti-Rib-P types. The serological hit rate provided by anti-dsDNA/anti-Sm detection (72.7%) was increased upon parallel testing for anti-Rib-P-C (77.3%) or anti-Rib-P0/P1/P2 (80.3%). Anti-Rib-P positivity was associated with disease activity, neuropsychiatric events, lupus nephritis, skin rash, lymphocytopenia, increased erythrocyte sedimentation rates, decreased complement C3/C4 and elevated IgA/IgG levels.

ConclusionBased on these results, antibodies against ribosomal P proteins are important complementary parameters to anti-dsDNA and anti-Sm, and should be considered for inclusion in the classification criteria for SLE. The diagnostic value of anti-Rib-P0/P1/P2 is diagnostically superior to that of anti-Rib-P-C. J. Clin. Lab. Anal. 27:87-95, 2013. (c) 2013 Wiley Periodicals, Inc.

语种英语
所属项目编号2006AA02Z495 ; 7072085
资助者National High Technology Research and Development Program of China (863 Program) ; Beijing Municipal Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; Beijing Municipal Natural Science Foundation
WOS记录号WOS:000329810800001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53937
Collection北京大学第二临床医学院
作者单位1.EUROIMMUN AG, Inst Expt Immunol, Lubeck, Germany
2.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Sch Med, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li, Jing,Shen, Ying,He, Jing,et al. Significance of Antibodies Against the Native Ribosomal P Protein Complex and Recombinant P0, P1, and P2 Proteins in the Diagnosis of Chinese Patients with Systemic Lupus Erythematosus[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2013,27(2):87-95.
APA Li, Jing.,Shen, Ying.,He, Jing.,Jia, Rulin.,Wang, Xiujie.,...&Li, Zhan-Guo.(2013).Significance of Antibodies Against the Native Ribosomal P Protein Complex and Recombinant P0, P1, and P2 Proteins in the Diagnosis of Chinese Patients with Systemic Lupus Erythematosus.JOURNAL OF CLINICAL LABORATORY ANALYSIS,27(2),87-95.
MLA Li, Jing,et al."Significance of Antibodies Against the Native Ribosomal P Protein Complex and Recombinant P0, P1, and P2 Proteins in the Diagnosis of Chinese Patients with Systemic Lupus Erythematosus".JOURNAL OF CLINICAL LABORATORY ANALYSIS 27.2(2013):87-95.
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