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Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-alpha,beta-aspartyl-L-alanine
Gui, Lin1; Zhao, Ming1; Wang, Yinye2; Qin, Yang1; Liu, Jiangyuan1; Peng, Shiqi1
关键词Concentration-dependent In Vitro Activity Concentration-dependent Nanofeature Dose-dependent In Vivo Activity Ph-dependent Nanofeature Sem Image Poly-alpha Tem Image Beta-dl-aspartyl-l-alanine
刊名NANOMEDICINE
2010-07-01
DOI10.2217/NNM.10.41
5期:5页:703-714
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
资助者PHR ; Natural Scientific Foundation of china ; PHR ; Natural Scientific Foundation of china
研究领域[WOS]Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
关键词[WOS]POLYASPARTIC ACID ; CALCIUM-CARBONATE ; GROWTH-KINETICS ; AQUEOUS-MEDIA ; THIN-FILMS ; NANOPARTICLES ; DELIVERY ; CHITOSAN ; MODELS ; AGENT
英文摘要

Applying nanoscale assembly to the design of a thrombolytic agent. Materials: Poly-alpha,beta-DL-aspartyl-L-alanine (molecular weight: 15726 atomic mass units) from the thermal polycondensation of DL-aspartic acid and the amidation of polysuccimide with L-alanine. Methods: The correlation of concentration and pH with nanofeatures, the correlation of concentration with in vitro thrombus lysis activity, the correlation of dose with the in vivo thrombolytic activity and the correlation of the dose with nanofeatures are all explained in this article. Results: Poly-alpha,beta-DL-aspartyl-L-alanine was concentration- (6.4 x 10(4,2,-4,-6,-8,-10,-12) nm) and pH-dependently (pH 1.2, 7.4 and 7.6) assembled to various nanospecies, exhibited concentration-dependent (4, 8 and 16 mu M) lysis action in vitro and dose-dependent (5, 0.5 and 0.05 mu mol/kg) thrombolytic action in vivo. Conclusion: Upon entering the stomach, intestinal tract, blood and tissue fluids, poly-alpha,beta-DL-aspartyl-L-alanine assembled to small nanoparticles or nanoblocks to escape the entrapment by macrophages and exhibited desirable thrombolytic action.

语种英语
所属项目编号KM2009100-25009 ; KM2009100-25010 ; 20772082 ; 2008ZX09401-002
资助者PHR ; Natural Scientific Foundation of china ; PHR ; Natural Scientific Foundation of china
WOS记录号WOS:000280454400012
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53942
专题北京大学药学院
作者单位1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gui, Lin,Zhao, Ming,Wang, Yinye,et al. Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-alpha,beta-aspartyl-L-alanine[J]. NANOMEDICINE,2010,5(5):703-714.
APA Gui, Lin,Zhao, Ming,Wang, Yinye,Qin, Yang,Liu, Jiangyuan,&Peng, Shiqi.(2010).Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-alpha,beta-aspartyl-L-alanine.NANOMEDICINE,5(5),703-714.
MLA Gui, Lin,et al."Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-alpha,beta-aspartyl-L-alanine".NANOMEDICINE 5.5(2010):703-714.
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