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学科主题: 基础医学
题名:
Synthesis of the pentasaccharide repeating unit of latosillan
作者: Hua, YX; Xiao, JJ; Huang, YS; Du, YG
关键词: glycosylation ; latosillan ; cell differentiation ; oligosaccharides
刊名: CARBOHYDRATE RESEARCH
发表日期: 2006-02-06
DOI: 10.1016/j.carries.2005.11.007
卷: 341, 期:2, 页:191-197
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: MYELOID LEUKEMIC-CELLS ; DIFFERENTIATION INDUCERS ; CONVERGENT SYNTHESIS ; WALL POLYSACCHARIDE ; GROUP-A ; OLIGOSACCHARIDES ; GLYCOSYLATION ; TRISACCHARIDE ; EFFICIENT ; CORE
英文摘要:

A pentasaccharide, beta-D-Man-(1 -> 2)-[beta-D-GlcNAc-(1 -> 4)]-alpha-L-Rha-(1 -> 4)-alpha-L-Rha-(1 -> 4)-alpha-L-Rha-1-OC8H17, representing the repeating unit of latosillan, was convergently synthesized from the building blocks, ethyl 2,3-O-isopropylidene-1-thio-alpha-L-rhamnopyranoside, 2-O-acetyl-3,4,6-tri-O-belizyl-beta-D-glucopyranosyl trichloroacetimidate, and 3,4,6-tri-O-acetyl-2-deoxy-2phthalimido-beta-D-glueopyranosyl trichloroacetimidate under standard glycosylation conditions. The target pentasaccharide showed acceptable differentiation-inducing activity on HL-60 cell lines at the dosages of 10-50 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000234869700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53943
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100083, Peoples R China

Recommended Citation:
Hua, YX,Xiao, JJ,Huang, YS,et al. Synthesis of the pentasaccharide repeating unit of latosillan[J]. CARBOHYDRATE RESEARCH,2006,341(2):191-197.
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