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Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow
Luo, Liman1; Liu, Die1; Tang, Chaoshu2,3; Du, Junbao1,3; Liu, Angie Dong4; Holmberg, Lukas4; Jin, Hongfang1
关键词Pulmonary Hypertension Pulmonary Vascular Remodeling Sulfur Dioxide Hydrogen Sulfide
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-04-19
DOI10.1016/j.bbrc.2013.03.014
433期:4页:519-525
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INDUCED MYOCARDIAL INJURY ; ARTERIAL-HYPERTENSION ; CARDIOVASCULAR-SYSTEM ; NEUTROPHILS ; MEDIATORS ; STRESS
英文摘要

Pulmonary hypertension (PH) is an important pathophysiological process in the development of many diseases. However, the mechanism responsible for the development of PH remains unknown. The objective of the study was to explore the possible impact of sulfur dioxide (SO2) on the endogenous hydrogen sulfide (H2S) pathway in rats with PH induced by high pulmonary blood flow. Compared with sham group, the systolic pulmonary artery pressure (SPAP) in the shunt group was significantly increased, along with the increased percentage of muscularized arteries and partially muscularized arteries of small pulmonary arteries. Compared with the shunt group, SPAP in the shunt + SO2 group was significantly decreased, and the percentage of muscularized pulmonary arteries was also decreased. Additionally, rats that developed PH had significantly lower levels of SO2 concentration, aspartate aminotransferase (AAT) activity, protein and mRNA expressions of AAT2 in pulmonary tissues. Administration of an SO2 donor could alleviate the elevated pulmonary arterial pressure and decrease the muscularization of pulmonary arteries. At the same time, it increased the H2S production, protein expression of cystathionine-gamma-lyase (CSE), mRNA expression of CSE, mercaptopyruvate transsulphurase (MPST) and cystathionine-beta-synthase (CBS) in the pulmonary tissue of the rats. The results suggested that endogenous SO2/AAT2 pathway and the endognous H2S production were downregulated in rats with PH induced by high pulmonary blood flow. However, SO2 could reduce pulmonary arterial pressure and improve the pulmonary vascular pathological changes in association with upregulating endogenous H2S pathway. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000318259100028
项目编号7112130 ; 2011CB503904 ; 2012CB517806 ; 81121061 ; 810701 11 ; 31130030
资助机构Beijing Natural Science Foundation ; Major Basic Research Development Program of People&prime ; s Republic of China ; National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53948
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
4.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
推荐引用方式
GB/T 7714
Luo, Liman,Liu, Die,Tang, Chaoshu,et al. Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,433(4):519-525.
APA Luo, Liman.,Liu, Die.,Tang, Chaoshu.,Du, Junbao.,Liu, Angie Dong.,...&Jin, Hongfang.(2013).Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,433(4),519-525.
MLA Luo, Liman,et al."Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 433.4(2013):519-525.
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