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学科主题: 临床医学
题名:
Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow
作者: Luo, Liman1; Liu, Die1; Tang, Chaoshu2,3; Du, Junbao1,3; Liu, Angie Dong4; Holmberg, Lukas4; Jin, Hongfang1
关键词: Pulmonary hypertension ; Pulmonary vascular remodeling ; Sulfur dioxide ; Hydrogen sulfide
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2013-04-19
DOI: 10.1016/j.bbrc.2013.03.014
卷: 433, 期:4, 页:519-525
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: INDUCED MYOCARDIAL INJURY ; ARTERIAL-HYPERTENSION ; CARDIOVASCULAR-SYSTEM ; NEUTROPHILS ; MEDIATORS ; STRESS
英文摘要:

Pulmonary hypertension (PH) is an important pathophysiological process in the development of many diseases. However, the mechanism responsible for the development of PH remains unknown. The objective of the study was to explore the possible impact of sulfur dioxide (SO2) on the endogenous hydrogen sulfide (H2S) pathway in rats with PH induced by high pulmonary blood flow. Compared with sham group, the systolic pulmonary artery pressure (SPAP) in the shunt group was significantly increased, along with the increased percentage of muscularized arteries and partially muscularized arteries of small pulmonary arteries. Compared with the shunt group, SPAP in the shunt + SO2 group was significantly decreased, and the percentage of muscularized pulmonary arteries was also decreased. Additionally, rats that developed PH had significantly lower levels of SO2 concentration, aspartate aminotransferase (AAT) activity, protein and mRNA expressions of AAT2 in pulmonary tissues. Administration of an SO2 donor could alleviate the elevated pulmonary arterial pressure and decrease the muscularization of pulmonary arteries. At the same time, it increased the H2S production, protein expression of cystathionine-gamma-lyase (CSE), mRNA expression of CSE, mercaptopyruvate transsulphurase (MPST) and cystathionine-beta-synthase (CBS) in the pulmonary tissue of the rats. The results suggested that endogenous SO2/AAT2 pathway and the endognous H2S production were downregulated in rats with PH induced by high pulmonary blood flow. However, SO2 could reduce pulmonary arterial pressure and improve the pulmonary vascular pathological changes in association with upregulating endogenous H2S pathway. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 7112130 ; 2011CB503904 ; 2012CB517806 ; 81121061 ; 810701 11 ; 31130030
项目资助者: Beijing Natural Science Foundation ; Major Basic Research Development Program of People&prime ; s Republic of China ; National Natural Science Foundation of China
WOS记录号: WOS:000318259100028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53948
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
4.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden

Recommended Citation:
Luo, Liman,Liu, Die,Tang, Chaoshu,et al. Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,433(4):519-525.
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