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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
IL-35 inhibits acute graft-versus-host disease in a mouse model
作者: Zhang, Xiao-Hui1,2; Zhou, Yi1; Zhang, Jia-Min1; Zhou, Shi-Yuan1,2; Wang, Min1; Feng, Ru3; Feng, Fer-Er1; Wang, Qian-Ming1; Zhu, Xiao-Lu1; Zhao, Xiao-Su1; Lv, Meng1; Kong, Yuan1; Chang, Ying-Jun1; Huang, Xiao-Jun1,2
关键词: Bone marrow transplantation ; Acute graft-versus-host disease ; IL-35 ; Rapamycin
刊名: INTERNATIONAL IMMUNOPHARMACOLOGY
发表日期: 2015-12-01
DOI: 10.1016/j.intimp.2015.10.025
卷: 29, 期:2, 页:383-392
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Pharmacology & Pharmacy
研究领域[WOS]: Immunology ; Pharmacology & Pharmacy
关键词[WOS]: REGULATORY T-CELLS ; BONE-MARROW-TRANSPLANTATION ; INDUCED GENE 3 ; INTERFERON-GAMMA ; RAPAMYCIN INHIBITION ; MICE ; SIROLIMUS ; ARTHRITIS ; CYTOKINE ; ENCEPHALOMYELITIS
英文摘要:

Acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our previous study found that the novel anti-inflammatory cytokine IL-35 could suppress aGVHD in patients after allo-HSCT. In this study, we used C57BL/6 (B6, H-2b) mice as donors and (B6 x DBA/2) F1 (BDF1, H-2b x d) mice as recipients to create a model of aGVHD and explore the relationship between IL-35 and aGVHD. The mice receiving IL-35 survived longer than did the control mice. We observed that treatment with IL-35 and RAPA could reduce the incidence of aGVHD. Additionally, this treatment inhibited intestinal and thymic epithelial cell apoptosis and liver infiltration by the donor T-cells, thereby ameliorating the enteropathy and liver injury caused by aGVHD. We found that IL-35 and RAPA also markedly suppressed TNF-alpha and IL-17A expression and enhanced IFN-gamma expression in the intestine and liver. We measured Tregs in spleen and found that IL-35 and RAPA treatment expanded the number of Tregs in spleen. We found that the phosphorylation of STAT1 and STAT4 were inhibited in mice with aGVHD. In contrast, STAT1 and STAT4 were phosphorylated when the mice were treated with IL-35. IL-35 may have therapeutic potential in the treatment of aGVHD after allo-HSCT. (C) 2015 Published by Elsevier B.V.

语种: 英语
所属项目编号: 81270643 ; 81470343 ; 2012BAI38B03 ; 2141000008
项目资助者: National Natural Science Foundation of China ; National Key Technology Support Program ; Seeding Grant for Medicine and Engineering Sciences of Peking University
WOS记录号: WOS:000366764800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53956
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Minist Hlth, Beijing Hosp, Dept Hematol, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Collaborat Innovat Ctr Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Xiao-Hui,Zhou, Yi,Zhang, Jia-Min,et al. IL-35 inhibits acute graft-versus-host disease in a mouse model[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2015,29(2):383-392.
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