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学科主题临床医学
IL-35 inhibits acute graft-versus-host disease in a mouse model
Zhang, Xiao-Hui1,2; Zhou, Yi1; Zhang, Jia-Min1; Zhou, Shi-Yuan1,2; Wang, Min1; Feng, Ru3; Feng, Fer-Er1; Wang, Qian-Ming1; Zhu, Xiao-Lu1; Zhao, Xiao-Su1; Lv, Meng1; Kong, Yuan1; Chang, Ying-Jun1; Huang, Xiao-Jun1,2
关键词Bone Marrow Transplantation Acute Graft-versus-host Disease Il-35 Rapamycin
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
2015-12-01
DOI10.1016/j.intimp.2015.10.025
29期:2页:383-392
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Pharmacology & Pharmacy
研究领域[WOS]Immunology ; Pharmacology & Pharmacy
关键词[WOS]REGULATORY T-CELLS ; BONE-MARROW-TRANSPLANTATION ; INDUCED GENE 3 ; INTERFERON-GAMMA ; RAPAMYCIN INHIBITION ; MICE ; SIROLIMUS ; ARTHRITIS ; CYTOKINE ; ENCEPHALOMYELITIS
英文摘要

Acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our previous study found that the novel anti-inflammatory cytokine IL-35 could suppress aGVHD in patients after allo-HSCT. In this study, we used C57BL/6 (B6, H-2b) mice as donors and (B6 x DBA/2) F1 (BDF1, H-2b x d) mice as recipients to create a model of aGVHD and explore the relationship between IL-35 and aGVHD. The mice receiving IL-35 survived longer than did the control mice. We observed that treatment with IL-35 and RAPA could reduce the incidence of aGVHD. Additionally, this treatment inhibited intestinal and thymic epithelial cell apoptosis and liver infiltration by the donor T-cells, thereby ameliorating the enteropathy and liver injury caused by aGVHD. We found that IL-35 and RAPA also markedly suppressed TNF-alpha and IL-17A expression and enhanced IFN-gamma expression in the intestine and liver. We measured Tregs in spleen and found that IL-35 and RAPA treatment expanded the number of Tregs in spleen. We found that the phosphorylation of STAT1 and STAT4 were inhibited in mice with aGVHD. In contrast, STAT1 and STAT4 were phosphorylated when the mice were treated with IL-35. IL-35 may have therapeutic potential in the treatment of aGVHD after allo-HSCT. (C) 2015 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000366764800019
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53956
专题北京大学第二临床医学院_血液科
作者单位1.Minist Hlth, Beijing Hosp, Dept Hematol, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Collaborat Innovat Ctr Hematol, Beijing 100044, Peoples R China
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GB/T 7714
Zhang, Xiao-Hui,Zhou, Yi,Zhang, Jia-Min,et al. IL-35 inhibits acute graft-versus-host disease in a mouse model[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2015,29(2):383-392.
APA Zhang, Xiao-Hui.,Zhou, Yi.,Zhang, Jia-Min.,Zhou, Shi-Yuan.,Wang, Min.,...&Huang, Xiao-Jun.(2015).IL-35 inhibits acute graft-versus-host disease in a mouse model.INTERNATIONAL IMMUNOPHARMACOLOGY,29(2),383-392.
MLA Zhang, Xiao-Hui,et al."IL-35 inhibits acute graft-versus-host disease in a mouse model".INTERNATIONAL IMMUNOPHARMACOLOGY 29.2(2015):383-392.
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