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学科主题临床医学
Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells
Chu, Ryan1; Liu, Shirley Y. W.2; Vlantis, Alexander C.1; van Hasselt, C. Andrew1; Ng, Enders K. W.2; Fan, Michael Dahua1; Ng, Siu Kwan1; Chan, Amy S. W.3; Du, Jing4; Wei, Wei4; Liu, Xiaoling4; Liu, Zhimin5; Chen, George G.2
关键词Thyroid Cancer Foxp3 Ppar Gamma Apoptosis
刊名MOLECULAR AND CELLULAR ENDOCRINOLOGY
2015-01-05
DOI10.1016/j.mce.2014.10.006
399期:C页:228-234
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]Cell Biology ; Endocrinology & Metabolism
关键词[WOS]REGULATORY T-CELLS ; ACTIVATED-RECEPTOR-GAMMA ; PPAR-GAMMA ; LUNG-CANCER ; SIGNALING PATHWAY ; CARCINOMA CELLS ; TUMOR ; EXPRESSION ; LYMPHOCYTES ; SENSITIVITY
英文摘要

Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Foxp3 decreased cell proliferation and migration, but increased apoptosis, suggesting a positive role of Foxp3 in cancer growth. Interestingly, Foxp3 inhibition enhanced PPAR gamma expression and activity. In addition, Foxp3 inhibition downregulated NF-kappa B subunit p65 and cyclin D1 but upregulated caspase-3 levels. These molecular changes are in line with Foxp3 shRNA-mediated alteration of cell functions. Collectively, our study demonstrates that thyroid cancer cells express a high level of functional Foxp3 and that the inhibition of the Foxp3 suppresses the proliferation and migration but promotes apoptosis, suggesting that targeting Foxp3 in thyroid cancer cells may offer a novel therapeutic option for thyroid cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000348877700024
项目编号2011.1.055 ; 2013.1.011
资助机构Chinese University of Hong Kong
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53958
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
2.Prince Wales Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shatin, Hong Kong, Peoples R China
3.Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
5.Chongqing Med Univ, Fac Basic Med Sci, Dept Biochem & Mol Biol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Chu, Ryan,Liu, Shirley Y. W.,Vlantis, Alexander C.,et al. Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2015,399(C):228-234.
APA Chu, Ryan.,Liu, Shirley Y. W..,Vlantis, Alexander C..,van Hasselt, C. Andrew.,Ng, Enders K. W..,...&Chen, George G..(2015).Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells.MOLECULAR AND CELLULAR ENDOCRINOLOGY,399(C),228-234.
MLA Chu, Ryan,et al."Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells".MOLECULAR AND CELLULAR ENDOCRINOLOGY 399.C(2015):228-234.
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