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Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu
Pang, Lulu; Qi, Jianguang; Gao, Yang; Jin, Hongfang; Du, Junbao
关键词Pulmonary Hypertension High Pulmonary Blood Flow Collagen Adrenomedullin
刊名PEPTIDES
2014-04-01
DOI10.1016/j.peptides.2014.01.013
54页:101-107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE ; MONOCROTALINE ; HYPOXIA ; HYPERTROPHY ; FIBROBLASTS ; INHALATION ; EXPRESSION ; FIBROSIS ; SURVIVAL ; DISEASE
英文摘要

Collagen accumulation is one of the important pathologic changes in the development of pulmonary hypertension. Previous research showed that adrenomedullin (ADM) mitigates the development of pulmonary hypertension. The present study explored the role of ADM in the development of pulmonary artery collagen accumulation induced by high pulmonary blood flow, by investigating the effect of ADM [1.5 mu g/(kg h)] subcutaneously administered by mini-osmotic pump on pulmonary hemodynamics, pulmonary vascular structure and pulmonary artery collagen accumulation and synthesis in rats with high pulmonary blood flow induced by aortocaval shunting. The results showed that ADM significantly decreased mean pulmonary artery pressure (mPAP) and the ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV + SP)], attenuated the muscularization of small pulmonary vessels and relative medial thickness (RMT) of pulmonary arteries in rats with high pulmonary blood flow. Meanwhile, ADM ameliorated pulmonary artery collagen deposition represented by a decrease in lung tissue hydroxyproline, collagens I and III content and pulmonary artery collagens I and III expression, reduced collagen synthesis represented by a decrease in lung tissue procollagens I and III mRNA expression. The results suggest that ADM plays a protective role in the development of pulmonary hypertension induced by high blood flow, by inhibiting pulmonary procollagen synthesis and alleviating pulmonary artery collagen accumulation. (c) 2014 Elsevier Inc. All rights reserved.

语种英语
所属项目编号30973226
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000334508400013
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53960
专题北京大学第一临床医学院_儿科
作者单位Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Pang, Lulu,Qi, Jianguang,Gao, Yang,et al. Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu[J]. PEPTIDES,2014,54:101-107.
APA Pang, Lulu,Qi, Jianguang,Gao, Yang,Jin, Hongfang,&Du, Junbao.(2014).Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu.PEPTIDES,54,101-107.
MLA Pang, Lulu,et al."Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu".PEPTIDES 54(2014):101-107.
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