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学科主题: 临床医学
题名:
Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu
作者: Pang, Lulu; Qi, Jianguang; Gao, Yang; Jin, Hongfang; Du, Junbao
关键词: Pulmonary hypertension ; High pulmonary blood flow ; Collagen ; Adrenomedullin
刊名: PEPTIDES
发表日期: 2014-04-01
DOI: 10.1016/j.peptides.2014.01.013
卷: 54, 页:101-107
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE ; MONOCROTALINE ; HYPOXIA ; HYPERTROPHY ; FIBROBLASTS ; INHALATION ; EXPRESSION ; FIBROSIS ; SURVIVAL ; DISEASE
英文摘要:

Collagen accumulation is one of the important pathologic changes in the development of pulmonary hypertension. Previous research showed that adrenomedullin (ADM) mitigates the development of pulmonary hypertension. The present study explored the role of ADM in the development of pulmonary artery collagen accumulation induced by high pulmonary blood flow, by investigating the effect of ADM [1.5 mu g/(kg h)] subcutaneously administered by mini-osmotic pump on pulmonary hemodynamics, pulmonary vascular structure and pulmonary artery collagen accumulation and synthesis in rats with high pulmonary blood flow induced by aortocaval shunting. The results showed that ADM significantly decreased mean pulmonary artery pressure (mPAP) and the ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV + SP)], attenuated the muscularization of small pulmonary vessels and relative medial thickness (RMT) of pulmonary arteries in rats with high pulmonary blood flow. Meanwhile, ADM ameliorated pulmonary artery collagen deposition represented by a decrease in lung tissue hydroxyproline, collagens I and III content and pulmonary artery collagens I and III expression, reduced collagen synthesis represented by a decrease in lung tissue procollagens I and III mRNA expression. The results suggest that ADM plays a protective role in the development of pulmonary hypertension induced by high blood flow, by inhibiting pulmonary procollagen synthesis and alleviating pulmonary artery collagen accumulation. (c) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30973226
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000334508400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53960
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Pang, Lulu,Qi, Jianguang,Gao, Yang,et al. Adrenomedullin alleviates pulmonary artery collagen accumulationin rats with pulmonary hypertension induced by high blood flowLulu[J]. PEPTIDES,2014,54:101-107.
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