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学科主题: 临床医学
题名:
Efficacy of physical examination, ultrasound, and ultrasound combined with fine-needle aspiration for axilla staging of primary breast cancer
作者: Feng, Yu1; Huang, Rui1; He, Yingjian1; Lu, Aiping2; Fan, Zhaoqing1; Fan, Tie1; Qi, Meng1; Wang, Xinguang1; Cao, Wei1; Wang, Xing1; Xie, Yuntao1; Wang, Tianfeng1; Li, Jinfeng1; Ouyang, Tao1
关键词: Ultrasonography ; Fine-needle axillary biopsy ; Axillary staging ; Sentinel lymph node biopsy
刊名: BREAST CANCER RESEARCH AND TREATMENT
发表日期: 2015-02-01
DOI: 10.1007/s10549-015-3280-z
卷: 149, 期:3, 页:761-765
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: LYMPH-NODE BIOPSY ; SENTINEL NODE ; PREOPERATIVE ULTRASONOGRAPHY ; METASTASES ; MAMMOGRAPHY ; CARCINOMA ; DIAGNOSIS ; ACCURACY ; CYTOLOGY ; MANAGEMENT
英文摘要:

The aim of this study was to compare the efficacy of physical examination (PE), ultrasound (US), and US combined with fine-needle cytology (US-FNAC) in evaluation of node status before sentinel lymph node biopsy (SLNB) for breast cancer patients. We performed a retrospective study of 3,781 breast cancer patients and calculated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for PE, US, and US-FNAC, respectively. A total of 3,175 cases were documented as cN(0) and 606 as cN(1). Abnormal axillary nodes under US were detected in 1,152 cases, among which 821 were proven to have positive nodes by FNAC. The positive FNAC results enabled 11.7 % of cN(0) patients (373/3,175) to avoid unnecessary SLNB. All 331 cases with abnormal US but negative FNAC results, and the 2,629 cases with normal US underwent SLNB procedure for nodal staging, and metastatic nodes were identified in 745 patients. The sensitivity of PE was 32.2 %, with a specificity of 95.5 %, a PPV of 83.5 %, a NPV of 65 %, and an accuracy of 69.3 %. The sensitivity, specificity, PPV, NPV, and accuracy of axillary US alone were 58.6, 89.4, 79.6, 75.3, and 76.7 %, respectively. Combining axillary US with FNAC resulted in sensitivity, specificity, PPV, NPV, and accuracy of 52.4, 100, 100, 74.8, and 80.3 %, respectively. Our study demonstrated that US-FNAC is a feasible and effective triage during axillary staging for newly diagnosed breast cancer patients.

语种: 英语
WOS记录号: WOS:000349761200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53968
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ Canc Hosp & Inst, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Peking Univ Canc Hosp & Inst, Minist Educ, Dept Pathol, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Feng, Yu,Huang, Rui,He, Yingjian,et al. Efficacy of physical examination, ultrasound, and ultrasound combined with fine-needle aspiration for axilla staging of primary breast cancer[J]. BREAST CANCER RESEARCH AND TREATMENT,2015,149(3):761-765.
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