IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population
Wang, M; Xing, ZM; Yu, DL; Yan, Z; Yu, LS
刊名OTOLARYNGOLOGY-HEAD AND NECK SURGERY
2004-02-01
DOI10.1067/j.otohns.2003.08.012
130期:2页:192-196
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology ; Surgery
研究领域[WOS]Otorhinolaryngology ; Surgery
关键词[WOS]SENSITIVE ASTHMA ; GENETICS ; PRIMERS
英文摘要

OBJECTIVE: The aim of the study was to determine whether susceptibility or resistance to Artemisia pollen-induced allergic rhinitis was associated with H LA class II DQA1, DQB1 loci.

STUDY DESIGN AND SETTING: Forty-one subjects with allergic rhinitis and 41 healthy controls from Beijing were genotyped at HLA class II DQA1, DQB1 alleles by polymerase chain reaction amplification with sequence-specific primers-based technique.

RESULTS. The allele frequencies of HLA-DQA1*0201, DQB1*0602 were lower in patients with allergic rhinitis compared with the controls (24.39% versus 46.34%, P = 0.038; 4.88% versus 26.83%, P = 0.007), and the frequency of DQA1*0302 was higher among patients than the controls (58.54% versus 14.63%, P = 0.00004, Pc = 0.0004).

CONCLUSION AND SIGNIFICANCE. HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis.

语种英语
WOS记录号WOS:000189317300006
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53975
Collection北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept ENT, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Wang, M,Xing, ZM,Yu, DL,et al. Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY,2004,130(2):192-196.
APA Wang, M,Xing, ZM,Yu, DL,Yan, Z,&Yu, LS.(2004).Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population.OTOLARYNGOLOGY-HEAD AND NECK SURGERY,130(2),192-196.
MLA Wang, M,et al."Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population".OTOLARYNGOLOGY-HEAD AND NECK SURGERY 130.2(2004):192-196.
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