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学科主题: 临床医学
题名:
Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population
作者: Wang, M; Xing, ZM; Yu, DL; Yan, Z; Yu, LS
刊名: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
发表日期: 2004-02-01
DOI: 10.1067/j.otohns.2003.08.012
卷: 130, 期:2, 页:192-196
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Otorhinolaryngology ; Surgery
研究领域[WOS]: Otorhinolaryngology ; Surgery
关键词[WOS]: SENSITIVE ASTHMA ; GENETICS ; PRIMERS
英文摘要:

OBJECTIVE: The aim of the study was to determine whether susceptibility or resistance to Artemisia pollen-induced allergic rhinitis was associated with H LA class II DQA1, DQB1 loci.

STUDY DESIGN AND SETTING: Forty-one subjects with allergic rhinitis and 41 healthy controls from Beijing were genotyped at HLA class II DQA1, DQB1 alleles by polymerase chain reaction amplification with sequence-specific primers-based technique.

RESULTS. The allele frequencies of HLA-DQA1*0201, DQB1*0602 were lower in patients with allergic rhinitis compared with the controls (24.39% versus 46.34%, P = 0.038; 4.88% versus 26.83%, P = 0.007), and the frequency of DQA1*0302 was higher among patients than the controls (58.54% versus 14.63%, P = 0.00004, Pc = 0.0004).

CONCLUSION AND SIGNIFICANCE. HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis.

语种: 英语
WOS记录号: WOS:000189317300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53975
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept ENT, Beijing 100044, Peoples R China

Recommended Citation:
Wang, M,Xing, ZM,Yu, DL,et al. Association between HLA class II locus and the susceptibility to Artemisio pollen-induced allergic rhinitis in Chinese population[J]. OTOLARYNGOLOGY-HEAD AND NECK SURGERY,2004,130(2):192-196.
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