北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies
作者: Zhu, Hong-Yun1,2; Li, Miao-Xin1; Yang, Dong-Hui1; Tao, Yi-Lun1; Zhang, Ying1; Liu, Shu-Lin2,3,4
关键词: Enterodiol ; Defatted flaxseed ; Biotransformation ; Bacteroides uniformis ; Eubacterium limosum ; Eggerthella lenta
刊名: PROCESS BIOCHEMISTRY
发表日期: 2014
DOI: 10.1016/j.procbio.2013.10.003
卷: 49, 期:1, 页:19-24
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering, Chemical
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering
关键词[WOS]: HUMAN INTESTINAL BACTERIA ; LIGNAN SECOISOLARICIRESINOL DIGLUCOSIDE ; PLANT LIGNANS ; MAMMALIAN LIGNANS ; IN-VIVO ; ENTEROLACTONE ; ENTERODIOL ; METABOLISM ; PRECURSORS ; CANCER
英文摘要:

Enterodiol (END) possesses the estrogenic and antiestrogenic activities, which could prevent the development of breast cancer and prostate cancer, as well as menopausal syndrome.

Previous studies in our laboratory set up a bio-transformation method for largely yielding secoisolariciresinol (SECO) from the substrate of defatted flaxseeds by strain Bacteroides umformis ZL-I. In this research, another two single colonies, designated as strain ZL-II and strain ZL-III, were isolated, which were closely related to Eubacterium limosum species (ZL-II), and Eggerthella lento species (ZL-III) on the basis of 16S rRNA gene sequence data. Under the combining actions of strains ZL-(I+II+III), END could be produced from defatted flaxseed directly, ZL-II was proved to possess the activities of demethylation, while ZL-III had the activities of dehydroxylation. Secoisolariciresinol diglucoside (SDG) existed in the form of oligomeric with 3-hydroxy-3-methyl glutaric acid in flaxseed could be efficiently transformed into END under the co-culture of strains ZL-(I+II+III), with the conversion rate of more than 90%. The method for mass-producing END from defatted flaxseed reported here is meaningful not only for the medicinal values of END but also for the resource utilization of flaxseed materials. (C) 2013 Published by Elsevier Ltd.

语种: 英语
所属项目编号: 30672622 ; 21072012 ; 2011ZX09102-011-06
项目资助者: National Natural Science Foundation of China ; National Science and Technology Major Projects for Major New Drugs Innovation and Development of China
WOS记录号: WOS:000331156100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53979
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Harbin Med Univ, Genom Res Ctr, Harbin 150081, Peoples R China
4.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada

Recommended Citation:
Zhu, Hong-Yun,Li, Miao-Xin,Yang, Dong-Hui,et al. Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies[J]. PROCESS BIOCHEMISTRY,2014,49(1):19-24.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, Hong-Yun]'s Articles
[Li, Miao-Xin]'s Articles
[Yang, Dong-Hui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, Hong-Yun]‘s Articles
[Li, Miao-Xin]‘s Articles
[Yang, Dong-Hui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace