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Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies
Zhu, Hong-Yun1,2; Li, Miao-Xin1; Yang, Dong-Hui1; Tao, Yi-Lun1; Zhang, Ying1; Liu, Shu-Lin2,3,4
关键词Enterodiol Defatted Flaxseed Biotransformation Bacteroides Uniformis Eubacterium Limosum Eggerthella Lenta
刊名PROCESS BIOCHEMISTRY
2014
DOI10.1016/j.procbio.2013.10.003
49期:1页:19-24
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering, Chemical
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering
关键词[WOS]HUMAN INTESTINAL BACTERIA ; LIGNAN SECOISOLARICIRESINOL DIGLUCOSIDE ; PLANT LIGNANS ; MAMMALIAN LIGNANS ; IN-VIVO ; ENTEROLACTONE ; ENTERODIOL ; METABOLISM ; PRECURSORS ; CANCER
英文摘要

Enterodiol (END) possesses the estrogenic and antiestrogenic activities, which could prevent the development of breast cancer and prostate cancer, as well as menopausal syndrome.

Previous studies in our laboratory set up a bio-transformation method for largely yielding secoisolariciresinol (SECO) from the substrate of defatted flaxseeds by strain Bacteroides umformis ZL-I. In this research, another two single colonies, designated as strain ZL-II and strain ZL-III, were isolated, which were closely related to Eubacterium limosum species (ZL-II), and Eggerthella lento species (ZL-III) on the basis of 16S rRNA gene sequence data. Under the combining actions of strains ZL-(I+II+III), END could be produced from defatted flaxseed directly, ZL-II was proved to possess the activities of demethylation, while ZL-III had the activities of dehydroxylation. Secoisolariciresinol diglucoside (SDG) existed in the form of oligomeric with 3-hydroxy-3-methyl glutaric acid in flaxseed could be efficiently transformed into END under the co-culture of strains ZL-(I+II+III), with the conversion rate of more than 90%. The method for mass-producing END from defatted flaxseed reported here is meaningful not only for the medicinal values of END but also for the resource utilization of flaxseed materials. (C) 2013 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000331156100003
项目编号30672622 ; 21072012 ; 2011ZX09102-011-06
资助机构National Natural Science Foundation of China ; National Science and Technology Major Projects for Major New Drugs Innovation and Development of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53979
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Harbin Med Univ, Genom Res Ctr, Harbin 150081, Peoples R China
4.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
推荐引用方式
GB/T 7714
Zhu, Hong-Yun,Li, Miao-Xin,Yang, Dong-Hui,et al. Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies[J]. PROCESS BIOCHEMISTRY,2014,49(1):19-24.
APA Zhu, Hong-Yun,Li, Miao-Xin,Yang, Dong-Hui,Tao, Yi-Lun,Zhang, Ying,&Liu, Shu-Lin.(2014).Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies.PROCESS BIOCHEMISTRY,49(1),19-24.
MLA Zhu, Hong-Yun,et al."Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies".PROCESS BIOCHEMISTRY 49.1(2014):19-24.
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