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学科主题: 临床医学
题名:
Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis
作者: Xiao, WB; Liu, YL
关键词: ascites ; cancer antigen 125 ; liver cirrhosis
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2003-11-01
卷: 18, 期:11, 页:1315-1316
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CA-125 ; MARKER
英文摘要:

Background and Aim: Serum cancer antigen (CA) 125 elevation has been reported in patients with liver disease, but it is poorly characterized. The present study aimed to evaluate the range of serum and ascitic CA 125 levels in patients with liver cirrhosis and to explore possible factors associated with CA 125 elevation.

Methods: A total of 70 patients were studied. Group I consisted of 30 patients with liver cirrhosis with or without ascites. Group II consisted of 30 patients with digestive malignant tumors with or without ascites. Group III consisted of 10 patients with benign ascites. The CA 125 levels were measured in the serum of all patients and also simultaneously in the ascitic fluid of 15 patients.

Results: Serum CA125 levels in 80% of (24/30) patients from group I were elevated, particularly in those with ascites, irrespective of the etiology of cirrhosis. Serum CA 125 levels were correlated with Child-Pugh scores (r = 0.38), but not significantly (P = 0.06). All patients from group II with ascites and from group III had elevated serum CA 125 levels, but there was no difference in the serum CA 125 levels between patients with ascites from group I (275 +/- 175 U/ mL), group II (368 +/- 190 U/ mL) or group III (396 +/- 287 U/ mL), nor was there a significant difference in ascitic CA 125 levels (P > 0.05). The levels of serum CA 125 (198 +/- 108 U/ mL) were lower than, but correlated with that of ascites (460 +/- 234 U/ mL, r = 0.58, P = 0.026). The elevation of serum CA 125 accompanied by abnormalities of other tumor markers was more common in malignant ascites than in benign ascites (90% compared with 6%, P < 0.05).

Conclusion: The elevation of serum CA 125 is common in patients with liver cirrhosis. It is related to the presence of ascites, and possibly to the insufficiency of liver function, but not the etiology of cirrhosis and ascites. Serum CA 125 probably comes from ascites. It usually predicts benign disease if the elevation of serum or ascites CA 125 is not accompanied by the abnormalities of other tumor markers. (C) 2003 Blackwell Publishing Asia Pty Ltd.

语种: 英语
WOS记录号: WOS:000185872200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53984
Appears in Collections:北京大学第二临床医学院_消化内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China

Recommended Citation:
Xiao, WB,Liu, YL. Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2003,18(11):1315-1316.
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