Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice

doi:10.1016/j.foodchem.2009.04.120

IR@PKUHSC > 北京大学公共卫生学院

学科主题	公共卫生
	Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice
	Pei, Xinrong 1; Yang, Ruiyue 1; Zhang, Zhaofeng1 ; Gao, Lifang 2; Wang, Junbo1 ; Xu, Yajun1 ; Zhao, Ming1 ; Han, Xiaolong 1; Liu, Zhigang 1; Li, Yong 1
关键词	Bioactive Peptides Learning And Memory Aging Brain-derived Neurotrophic Factor Postsynaptic Density Protein 95
刊名	FOOD CHEMISTRY
	2010-01-15
DOI	10.1016/j.foodchem.2009.04.120
卷	118 期:2 页:333-340
收录类别	SCI
文章类型	Article
WOS标题词	Science & Technology
类目[WOS]	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]	BIOACTIVE PEPTIDES ; ALZHEIMERS-DISEASE ; VASCULAR DEMENTIA ; AGING BRAIN ; ANTIOXIDANT ; RATS ; HIPPOCAMPAL ; MODULATION ; DEFICITS ; RECEPTOR
英文摘要	To observe the neuroprotective effects of marine collagen peptide (MCP) isolated from Chum Salmon (Oncorhynchus keta) skin by enzymatic hydrolysis, 20-month-old female C57BL/6J mice were fed with chow diet, 0.22%, 0.44% or 1.32% (wt/wt) MCP diet for 3 months. Comparing with aged control group, the abilities of passive avoidance and spatial memory and learning were significantly enhanced evaluated by step-down test and Morris water maze respectively. Furthermore, the abilities of learning and memory had no significant difference between 0.44% and 1.32% MCP treated groups and young control group. The alleviated oxidative stress, reduced apoptotic neurons, up-regulated expression of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) were observed in MCP treated groups compared with aged control group. Our research revealed that there were no significant difference between 0.44% and 1.32% MCP treated groups and young control group. These findings suggest that MCP could be a candidate for functional food to relieve memory deficits associated with aging. (C) 2009 Elsevier Ltd. All rights reserved.
语种	英语
WOS记录号	WOS:000270526300021
项目编号	2006BAD271308
资助机构	Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.bjmu.edu.cn/handle/400002259/53986
专题	北京大学公共卫生学院北京大学药学院_化学生物学系北京大学公共卫生学院_营养与食品卫生学系北京大学公共卫生学院_公共卫生学院
作者单位	1.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China 2.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Pei, Xinrong,Yang, Ruiyue,Zhang, Zhaofeng,et al. Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice[J]. FOOD CHEMISTRY,2010,118(2):333-340.
APA	Pei, Xinrong.,Yang, Ruiyue.,Zhang, Zhaofeng.,Gao, Lifang.,Wang, Junbo.,...&Li, Yong.(2010).Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice.FOOD CHEMISTRY,118(2),333-340.
MLA	Pei, Xinrong,et al."Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice".FOOD CHEMISTRY 118.2(2010):333-340.