IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice
Pei, Xinrong1; Yang, Ruiyue1; Zhang, Zhaofeng1; Gao, Lifang2; Wang, Junbo1; Xu, Yajun1; Zhao, Ming1; Han, Xiaolong1; Liu, Zhigang1; Li, Yong1
关键词Bioactive Peptides Learning And Memory Aging Brain-derived Neurotrophic Factor Postsynaptic Density Protein 95
刊名FOOD CHEMISTRY
2010-01-15
DOI10.1016/j.foodchem.2009.04.120
118期:2页:333-340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]BIOACTIVE PEPTIDES ; ALZHEIMERS-DISEASE ; VASCULAR DEMENTIA ; AGING BRAIN ; ANTIOXIDANT ; RATS ; HIPPOCAMPAL ; MODULATION ; DEFICITS ; RECEPTOR
英文摘要

To observe the neuroprotective effects of marine collagen peptide (MCP) isolated from Chum Salmon (Oncorhynchus keta) skin by enzymatic hydrolysis, 20-month-old female C57BL/6J mice were fed with chow diet, 0.22%, 0.44% or 1.32% (wt/wt) MCP diet for 3 months. Comparing with aged control group, the abilities of passive avoidance and spatial memory and learning were significantly enhanced evaluated by step-down test and Morris water maze respectively. Furthermore, the abilities of learning and memory had no significant difference between 0.44% and 1.32% MCP treated groups and young control group. The alleviated oxidative stress, reduced apoptotic neurons, up-regulated expression of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) were observed in MCP treated groups compared with aged control group. Our research revealed that there were no significant difference between 0.44% and 1.32% MCP treated groups and young control group. These findings suggest that MCP could be a candidate for functional food to relieve memory deficits associated with aging. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000270526300021
项目编号2006BAD271308
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53986
专题北京大学公共卫生学院
北京大学药学院_化学生物学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Pei, Xinrong,Yang, Ruiyue,Zhang, Zhaofeng,et al. Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice[J]. FOOD CHEMISTRY,2010,118(2):333-340.
APA Pei, Xinrong.,Yang, Ruiyue.,Zhang, Zhaofeng.,Gao, Lifang.,Wang, Junbo.,...&Li, Yong.(2010).Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice.FOOD CHEMISTRY,118(2),333-340.
MLA Pei, Xinrong,et al."Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice".FOOD CHEMISTRY 118.2(2010):333-340.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Pei, Xinrong]的文章
[Yang, Ruiyue]的文章
[Zhang, Zhaofeng]的文章
百度学术
百度学术中相似的文章
[Pei, Xinrong]的文章
[Yang, Ruiyue]的文章
[Zhang, Zhaofeng]的文章
必应学术
必应学术中相似的文章
[Pei, Xinrong]的文章
[Yang, Ruiyue]的文章
[Zhang, Zhaofeng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。