IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice
Pei, Xinrong1; Yang, Ruiyue1; Zhang, Zhaofeng1; Gao, Lifang2; Wang, Junbo1; Xu, Yajun1; Zhao, Ming1; Han, Xiaolong1; Liu, Zhigang1; Li, Yong1
关键词Bioactive Peptides Learning And Memory Aging Brain-derived Neurotrophic Factor Postsynaptic Density Protein 95
刊名FOOD CHEMISTRY
2010-01-15
DOI10.1016/j.foodchem.2009.04.120
118期:2页:333-340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]BIOACTIVE PEPTIDES ; ALZHEIMERS-DISEASE ; VASCULAR DEMENTIA ; AGING BRAIN ; ANTIOXIDANT ; RATS ; HIPPOCAMPAL ; MODULATION ; DEFICITS ; RECEPTOR
英文摘要

To observe the neuroprotective effects of marine collagen peptide (MCP) isolated from Chum Salmon (Oncorhynchus keta) skin by enzymatic hydrolysis, 20-month-old female C57BL/6J mice were fed with chow diet, 0.22%, 0.44% or 1.32% (wt/wt) MCP diet for 3 months. Comparing with aged control group, the abilities of passive avoidance and spatial memory and learning were significantly enhanced evaluated by step-down test and Morris water maze respectively. Furthermore, the abilities of learning and memory had no significant difference between 0.44% and 1.32% MCP treated groups and young control group. The alleviated oxidative stress, reduced apoptotic neurons, up-regulated expression of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) were observed in MCP treated groups compared with aged control group. Our research revealed that there were no significant difference between 0.44% and 1.32% MCP treated groups and young control group. These findings suggest that MCP could be a candidate for functional food to relieve memory deficits associated with aging. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2006BAD271308
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000270526300021
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53986
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Pei, Xinrong,Yang, Ruiyue,Zhang, Zhaofeng,et al. Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice[J]. FOOD CHEMISTRY,2010,118(2):333-340.
APA Pei, Xinrong.,Yang, Ruiyue.,Zhang, Zhaofeng.,Gao, Lifang.,Wang, Junbo.,...&Li, Yong.(2010).Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice.FOOD CHEMISTRY,118(2),333-340.
MLA Pei, Xinrong,et al."Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice".FOOD CHEMISTRY 118.2(2010):333-340.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Pei, Xinrong]'s Articles
[Yang, Ruiyue]'s Articles
[Zhang, Zhaofeng]'s Articles
百度学术
百度学术Similar articles in
[Pei, Xinrong]'s Articles
[Yang, Ruiyue]'s Articles
[Zhang, Zhaofeng]'s Articles
必应学术
必应学术Similar articles in
[Pei, Xinrong]'s Articles
[Yang, Ruiyue]'s Articles
[Zhang, Zhaofeng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.