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学科主题: 公共卫生
题名:
Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects
作者: Ren, Aiguo1,2; Qiu, Xinghua3,4; Jin, Lei1,2,4; Ma, Jin3; Li, Zhiwen1,2; Zhang, Le1,2; Zhu, Huiping5; Finnell, Richard H.5,6; Zhu, Tong3,4
关键词: congenital abnormalities ; indoor air pollution
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2011-08-02
DOI: 10.1073/pnas.1105209108
卷: 108, 期:31, 页:12770-12775
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ; MATERNAL PESTICIDE EXPOSURE ; CONGENITAL-ANOMALIES ; OXIDATIVE STRESS ; POPULATION ; HYPERTHERMIA ; CANCER ; DAMAGE ; FEVER ; CHINA
英文摘要:

Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case-control study was performed to explore the association between placental levels of selected POPs and risks for neural tube defects (NTDs) in a Chinese population with a high prevalence of NTDs. Cases included 80 fetuses or newborns with NTDs, whereas the controls were 50 healthy, nonmalformed newborn infants. Placental concentrations of polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers were analyzed by gas chromatography-mass spectrometry. The medians of PAHs, o,p′-isomers of dichlorodiphenyltrichloroethane (DDT) and metabolites, alpha- and gamma-hexachlorocyclohexane (HCH), and alpha-endosulfan were significantly higher in case placentas than in controls. PAH concentrations above the median were associated with a 4.52-fold (95% confidence interval (CI), 2.10-9.74) increased risk for any NTDs, and 5.84-(95% CI, 2.28-14.96) and 3.71-fold (95% CI, 1.57-8.79) increased risks for anencephaly and spina bifida, respectively. A dose-response relationship was observed between PAH levels and the risk of NTDs, with odds ratios for the second, third, and fourth quartiles, compared with the first, of 1.77-(95% CI, 0.66-4.76), 3.83-(95% CI, 1.37-10.75), and 11.67-fold (95% CI, 3.28-41.49), respectively. A dose-response relationship was observed for anencephaly and spina bifida subtypes. Similar results were observed for o,p′-DDT and metabolites, alpha-HCH, gamma-HCH, and alpha-endosulfan, whereas no dose-response relationship was observed for the last two pollutants. Elevated placental concentrations of PAHs, o,p′-DDT and metabolites, and alpha-HCH were associated with increased risks of NTDs in this population.

语种: 英语
所属项目编号: 20807003 ; 2007CB5119001 ; NS050249 ; HD058912
项目资助者: National Natural Science Foundation ; Key Development Program for Basic Research (People&prime ; s Republic of China) ; National Institutes of Health (United States)
WOS记录号: WOS:000293385700049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53988
Appears in Collections:北京大学公共卫生学院_北京大学生育健康研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Reprod & Child Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Peking Univ, State Key Joint Lab Environm Simulat & Pollut Con, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
5.Univ Texas Austin, Dell Pediat Res Inst, Dept Nutr Sci, Austin, TX 78723 USA
6.Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78723 USA

Recommended Citation:
Ren, Aiguo,Qiu, Xinghua,Jin, Lei,et al. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(31):12770-12775.
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