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学科主题: 精神卫生
题名:
Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design
作者: Chan, Raymond C. K.1,2,3; Wang, Ya1,2; Wang, Li2; Chen, Eric Y. H.3; Manschreck, Theo C.4; Li, Zhan-jiang5; Yu, Xin6; Gong, Qi-yong7
刊名: PLOS ONE
发表日期: 2009-12-24
DOI: 10.1371/journal.pone.0008469
卷: 4, 期:12
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SCHIZOPHRENIC-PATIENTS ; NEUROPSYCHOLOGICAL PERFORMANCE ; SUSTAINED ATTENTION ; ABNORMALITIES ; DYSFUNCTION ; INSTRUMENT ; ACTIVATION ; INVENTORY ; SYMPTOMS ; CHILDREN
英文摘要:

Background: Neurological soft signs and neurocognitive impairments have long been considered important features of schizophrenia. Previous correlational studies have suggested that there is a significant relationship between neurological soft signs and neurocognitive functions. The purpose of the current study was to examine the underlying relationships between these two distinct constructs with structural equation modeling (SEM).

Methods: 118 patients with schizophrenia and 160 healthy controls were recruited for the current study. The abridged version of the Cambridge Neurological Inventory (CNI) and a set of neurocognitive function tests were administered to all participants. SEM was then conducted independently in these two samples to examine the relationships between neurological soft signs and neurocognitive functions.

Results: Both the measurement and structural models showed that the models fit well to the data in both patients and healthy controls. The structural equations also showed that there were modest to moderate associations among neurological soft signs, executive attention, verbal memory, and visual memory, while the healthy controls showed more limited associations.

Conclusions: The current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample. Greater evidence of neurological soft signs is associated with more severe impairment of executive attention and memory functions. Clinical and theoretical implications of the model findings are discussed.

语种: 英语
所属项目编号: O7CX031003 ; KSCX2-YW-R-131 ; 30770723 ; 2007CB512302/5
项目资助者: Project-Oriented Hundred Talents Programme ; Chinese Academy of Sciences ; National Science Foundation of China ; National Basic Research Programme of China
WOS记录号: WOS:000273104000026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53991
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
6.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
7.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China

Recommended Citation:
Chan, Raymond C. K.,Wang, Ya,Wang, Li,et al. Neurological Soft Signs and Their Relationships to Neurocognitive Functions: A Re-Visit with the Structural Equation Modeling Design[J]. PLOS ONE,2009,4(12).
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