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学科主题临床医学
Fundus and histopathological study of radial optic neurotomy in the normal miniature pig eye
Tao, Y; Jiang, YR; Li, XX; Yin, CY; Yao, M
刊名ARCHIVES OF OPHTHALMOLOGY
2005-08-01
123期:8页:1097-1101
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]RETINAL VEIN OCCLUSION ; CIRCULATION ; ANASTOMOSIS
英文摘要

Objective: To demonstrate the fundus and histopathological changes in the normal miniature pig eye after radial optic neurotomy.

Methods: Ophthalmoscopic examinations, fundus photography, and fluorescein angiography were performed on 12 eyes that underwent radial optic neurotomy, 5 normal eyes, and 7 eyes that underwent vitrectomy (from 12 pigs in total) preoperatively and 1, 7, 14, 30, and 90 days postoperatively. These eyes were enucleated 120 days postoperatively. Sixteen eyes (of 8 pigs in total) that underwent radial optic neurotomy were enucleated 1, 3, 7, and 48 days (2 pigs each time) postoperatively. The enucleated eye sections were stained with hematoxylineosin, Masson trichrome, and Luxol fast blue.

Results: The retina radial to the site of radial optic neurotomy darkened gradually with the increasing curvature of the major retinal arteries. The filling time intervals from the retinal artery to the retinal vein were prolonged. At the incision site, there was a loss of nerve fibers, which were subsequently replaced by collagenous tissue. No anastomotic vessels formed by the end of the study.

Conclusions: Postoperatively, the retinal circulation seemed somewhat sluggish compared with that seen preoperatively. Segmental retinal nerve atrophy eventually formed. The procedure itself may not be the sole factor for the formation of shunt vessels.

Clinical Relevance: To date, radial optic neurotomy is controversial and persuasive animal studies are lacking. In combining fluorescein angiography with histopathological examination, this study may be somewhat helpful.

语种英语
WOS记录号WOS:000231236900010
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53993
专题北京大学第二临床医学院_眼科
作者单位Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Tao, Y,Jiang, YR,Li, XX,et al. Fundus and histopathological study of radial optic neurotomy in the normal miniature pig eye[J]. ARCHIVES OF OPHTHALMOLOGY,2005,123(8):1097-1101.
APA Tao, Y,Jiang, YR,Li, XX,Yin, CY,&Yao, M.(2005).Fundus and histopathological study of radial optic neurotomy in the normal miniature pig eye.ARCHIVES OF OPHTHALMOLOGY,123(8),1097-1101.
MLA Tao, Y,et al."Fundus and histopathological study of radial optic neurotomy in the normal miniature pig eye".ARCHIVES OF OPHTHALMOLOGY 123.8(2005):1097-1101.
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