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学科主题: 公共卫生
题名:
S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest
作者: Zhao Peng1,2; Fu Juan Ling1; Yao Bi Yun1,2; Jia Yong Rui3; Zhou Zong Can1
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2014-03-01
DOI: 10.3967/bes2014.044
卷: 27, 期:3, 页:215-219
收录类别: SCI
文章类型: Letter
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: 16HBE CELLS
英文摘要:

In this study, a new parameter, S phase cell percentage (S fraction) normalized BrdU (SFN-BrdU) incorporation rate, was introduced to detect S arrest. The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells. Theoretical analysis indicated that only S arrest could result in a decrease in the SFN-BrdU incorporation rate. Additionally, the decrease in SFN-BrdU incorporation rate and the activation of DNA damage checkpoints further demonstrated that S arrest was induced by diethyl sulfate treatment of 16HBE cells. In conclusion, SFN-BrdU incorporation rate can be used to detecting S arrest.

语种: 英语
WOS记录号: WOS:000334933300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53996
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhao Peng,Fu Juan Ling,Yao Bi Yun,et al. S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(3):215-219.
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