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S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest
Zhao Peng1,2; Fu Juan Ling1; Yao Bi Yun1,2; Jia Yong Rui3; Zhou Zong Can1
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2014-03-01
DOI10.3967/bes2014.044
27期:3页:215-219
收录类别SCI
文章类型Letter
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]16HBE CELLS
英文摘要

In this study, a new parameter, S phase cell percentage (S fraction) normalized BrdU (SFN-BrdU) incorporation rate, was introduced to detect S arrest. The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells. Theoretical analysis indicated that only S arrest could result in a decrease in the SFN-BrdU incorporation rate. Additionally, the decrease in SFN-BrdU incorporation rate and the activation of DNA damage checkpoints further demonstrated that S arrest was induced by diethyl sulfate treatment of 16HBE cells. In conclusion, SFN-BrdU incorporation rate can be used to detecting S arrest.

语种英语
WOS记录号WOS:000334933300010
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53996
专题北京大学公共卫生学院_毒理学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao Peng,Fu Juan Ling,Yao Bi Yun,et al. S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(3):215-219.
APA Zhao Peng,Fu Juan Ling,Yao Bi Yun,Jia Yong Rui,&Zhou Zong Can.(2014).S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,27(3),215-219.
MLA Zhao Peng,et al."S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 27.3(2014):215-219.
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