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学科主题临床医学
Bacterial Community Mapping of the Mouse Gastrointestinal Tract
Gu, Shenghua1; Chen, Dandan1; Zhang, Jin-Na1,2; Lv, Xiaoman3; Wang, Kun4; Duan, Li-Ping4; Nie, Yong1; Wu, Xiao-Lei1
刊名PLOS ONE
2013-10-07
DOI10.1371/journal.pone.0074957
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GUT MICROBIOTA ; MICE ; DIET ; DIVERSITY ; PHENOTYPE ; RESISTANT ; EVOLUTION ; MUTUALISM ; SEQUENCES ; DISEASE
英文摘要

Keeping mammalian gastrointestinal (GI) tract communities in balance is crucial for host health maintenance. However, our understanding of microbial communities in the GI tract is still very limited. In this study, samples taken from the GI tracts of C57BL/6 mice were subjected to 16S rRNA gene sequence-based analysis to examine the characteristic bacterial communities along the mouse GI tract, including those present in the stomach, duodenum, jejunum, ileum, cecum, colon and feces. Further analyses of the 283,234 valid sequences obtained from pyrosequencing revealed that the gastric, duodenal, large intestinal and fecal samples had higher phylogenetic diversity than the jejunum and ileum samples did. The microbial communities found in the small intestine and stomach were different from those seen in the large intestine and fecal samples. A greater proportion of Lactobacillaceae were found in the stomach and small intestine, while a larger proportion of anaerobes such as Bacteroidaceae, Prevotellaceae, Rikenellaceae, Lachnospiraceae, and Ruminococcaceae were found in the large intestine and feces. In addition, inter-mouse variations of microbiota were observed between the large intestinal and fecal samples, which were much smaller than those between the gastric and small intestinal samples. As far as we can ascertain, ours is the first study to systematically characterize bacterial communities from the GI tracts of C57BL/6 mice.

语种英语
WOS记录号WOS:000325501300019
项目编号2012BAI06B02
资助机构National "Twelfth Five-Year&prime ; &prime ; Plan for Science &amp ; Technology of China
引用统计
被引频次:91[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54000
专题北京大学第三临床医学院
北京大学医学部管理机构_科学研究处
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Kunming Med Univ, Kunming, Yunnan, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming, Yunnan, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Gu, Shenghua,Chen, Dandan,Zhang, Jin-Na,et al. Bacterial Community Mapping of the Mouse Gastrointestinal Tract[J]. PLOS ONE,2013,8(10).
APA Gu, Shenghua.,Chen, Dandan.,Zhang, Jin-Na.,Lv, Xiaoman.,Wang, Kun.,...&Wu, Xiao-Lei.(2013).Bacterial Community Mapping of the Mouse Gastrointestinal Tract.PLOS ONE,8(10).
MLA Gu, Shenghua,et al."Bacterial Community Mapping of the Mouse Gastrointestinal Tract".PLOS ONE 8.10(2013).
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