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学科主题: 临床医学
题名:
Bacterial Community Mapping of the Mouse Gastrointestinal Tract
作者: Gu, Shenghua1; Chen, Dandan1; Zhang, Jin-Na1,2; Lv, Xiaoman3; Wang, Kun4; Duan, Li-Ping4; Nie, Yong1; Wu, Xiao-Lei1
刊名: PLOS ONE
发表日期: 2013-10-07
DOI: 10.1371/journal.pone.0074957
卷: 8, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GUT MICROBIOTA ; MICE ; DIET ; DIVERSITY ; PHENOTYPE ; RESISTANT ; EVOLUTION ; MUTUALISM ; SEQUENCES ; DISEASE
英文摘要:

Keeping mammalian gastrointestinal (GI) tract communities in balance is crucial for host health maintenance. However, our understanding of microbial communities in the GI tract is still very limited. In this study, samples taken from the GI tracts of C57BL/6 mice were subjected to 16S rRNA gene sequence-based analysis to examine the characteristic bacterial communities along the mouse GI tract, including those present in the stomach, duodenum, jejunum, ileum, cecum, colon and feces. Further analyses of the 283,234 valid sequences obtained from pyrosequencing revealed that the gastric, duodenal, large intestinal and fecal samples had higher phylogenetic diversity than the jejunum and ileum samples did. The microbial communities found in the small intestine and stomach were different from those seen in the large intestine and fecal samples. A greater proportion of Lactobacillaceae were found in the stomach and small intestine, while a larger proportion of anaerobes such as Bacteroidaceae, Prevotellaceae, Rikenellaceae, Lachnospiraceae, and Ruminococcaceae were found in the large intestine and feces. In addition, inter-mouse variations of microbiota were observed between the large intestinal and fecal samples, which were much smaller than those between the gastric and small intestinal samples. As far as we can ascertain, ours is the first study to systematically characterize bacterial communities from the GI tracts of C57BL/6 mice.

语种: 英语
所属项目编号: 2012BAI06B02
项目资助者: National "Twelfth Five-Year&prime ; &prime ; Plan for Science &amp ; Technology of China
WOS记录号: WOS:000325501300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54000
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Kunming Med Univ, Kunming, Yunnan, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming, Yunnan, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Gu, Shenghua,Chen, Dandan,Zhang, Jin-Na,et al. Bacterial Community Mapping of the Mouse Gastrointestinal Tract[J]. PLOS ONE,2013,8(10).
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