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学科主题: 公共卫生
题名:
Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry
作者: Zeng Jing2; Yan Lai-Lai2; Ouyang Li2; Wang Jing-Yu1
关键词: Inductively coupled plasma mass spectrometry ; Lead ; Isotopic ratio ; Rats
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2011-08-01
DOI: 10.3724/SP.J.1096.2011.01176
卷: 39, 期:8, 页:1176-1180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: ICP-MS ; IDENTIFICATION ; CAIS
英文摘要:

A method was developed to simultaneously determine lead concentration and lead isotopic ratios in blood, hair, and other organs of lead exposed rats by inductively coupled plasma mass spectrometry(ICP-MS). The measurement value of lead concentration in standard material is (278 4) mu g/L, that is in the range of certified value (283 +/- 18) mu g/L, and the RSDs of Ph concentration, ratio (204)pb/(206)pb, (207)pb/(206)pb and (208)pb/(206) Pb of in the determination of 10 mu g/L Pb standard solution were less than 0.7%, 0.3%, 0.15% and 0.15%, respectively. It was found that RSD of isotopic ratios is stable when Pb concentration is more than 8 mu g/L. The concentration calculated by sum of of all Pb isotopes is more accurate and reasonable than that only by Pb-208. The measured results of samples from rats tissues show that there is a selective accumulation of Pb in different tissues and organs, Pb concentration from high to low is in femur, kidney, hair, liver and blood. Blood is more suitable than hair for biomarker to reflect inner Pb accumulation.

语种: 中文
WOS记录号: WOS:000296599800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54001
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China

Recommended Citation:
Zeng Jing,Yan Lai-Lai,Ouyang Li,et al. Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2011,39(8):1176-1180.
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