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Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry
Zeng Jing2; Yan Lai-Lai2; Ouyang Li2; Wang Jing-Yu1
关键词Inductively Coupled Plasma Mass Spectrometry Lead Isotopic Ratio Rats
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2011-08-01
DOI10.3724/SP.J.1096.2011.01176
39期:8页:1176-1180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]ICP-MS ; IDENTIFICATION ; CAIS
英文摘要

A method was developed to simultaneously determine lead concentration and lead isotopic ratios in blood, hair, and other organs of lead exposed rats by inductively coupled plasma mass spectrometry(ICP-MS). The measurement value of lead concentration in standard material is (278 4) mu g/L, that is in the range of certified value (283 +/- 18) mu g/L, and the RSDs of Ph concentration, ratio (204)pb/(206)pb, (207)pb/(206)pb and (208)pb/(206) Pb of in the determination of 10 mu g/L Pb standard solution were less than 0.7%, 0.3%, 0.15% and 0.15%, respectively. It was found that RSD of isotopic ratios is stable when Pb concentration is more than 8 mu g/L. The concentration calculated by sum of of all Pb isotopes is more accurate and reasonable than that only by Pb-208. The measured results of samples from rats tissues show that there is a selective accumulation of Pb in different tissues and organs, Pb concentration from high to low is in femur, kidney, hair, liver and blood. Blood is more suitable than hair for biomarker to reflect inner Pb accumulation.

语种中文
WOS记录号WOS:000296599800010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54001
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学第三临床医学院_介入血管外科
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China
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GB/T 7714
Zeng Jing,Yan Lai-Lai,Ouyang Li,et al. Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2011,39(8):1176-1180.
APA Zeng Jing,Yan Lai-Lai,Ouyang Li,&Wang Jing-Yu.(2011).Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,39(8),1176-1180.
MLA Zeng Jing,et al."Determination of Lead Concentration and Isotopic Ratios of Blood, Hair and Tissues in Rats by Inductively Coupled Plasma Mass Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 39.8(2011):1176-1180.
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