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学科主题: 临床医学
题名:
Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain
作者: Liu, Yiming; Feng, Yi; Zhang, Tingjie
关键词: Hyperpolarization-activated cyclic nucleotide-gated channel ; Pulsed radiofrequency ; Neuropathic pain ; Chronic constriction injury ; Neuromodulation
刊名: JOURNAL OF MOLECULAR NEUROSCIENCE
发表日期: 2015-09-01
DOI: 10.1007/s12031-015-0582-x
卷: 57, 期:1, 页:97-105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: PERIPHERAL-NERVE INJURY ; INDUCED TACTILE ALLODYNIA ; HCN2 ION CHANNELS ; CATION CHANNELS ; MECHANICAL ALLODYNIA ; PACEMAKER CHANNELS ; CONTRIBUTES ; HYPERSENSITIVITY ; HYPERALGESIA ; NEURONS
英文摘要:

Pulsed radiofrequency (PRF) treatment is a minimally invasive technique with multiple therapeutic applications. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel mediating Ih may regulate neuropathic pain signaling. This study aimed to determine whether PRF suppresses neuropathic pain by altering HCN channel expression in dorsal root ganglion (DRG) neurons. Male Sprague Dawley rats with sciatic nerve chronic constriction injury (CCI) were randomly assigned to PRF (n = 60) and sham control (n = 60) groups, respectively. On postoperative day 7 (D07), PRF or sham treatment was delivered to the proximal sciatic nerve for 8 min. Behavioral tests were performed before surgery (D0), on D07, and on D1, D7, and D14 after PRF or sham treatment. HCN1 and HCN2 expression levels in the DRG were examined by immunohistochemistry and Western blot. The results showed that thermal hyperalgesia, mechano-allodynia, and mechano-hyperalgesia were lower, and DRG expression levels of HCN1 and HCN2 higher, in the PRF group compared with sham control animals (all P < 0.05 at D14). In conclusion, PRF can upregulate HCN channel expression in the DRG of rats with sciatic nerve CCI. How this regulation of Ih in nociceptive afferents contributes to the suppression of neuropathic pain by PRF remains to be determined.

语种: 英语
项目资助者: Peking University People&prime ; s Hospital
WOS记录号: WOS:000360073300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54002
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Pain Med Dept, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Yiming,Feng, Yi,Zhang, Tingjie. Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2015,57(1):97-105.
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