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Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain
Liu, Yiming; Feng, Yi; Zhang, Tingjie
关键词Hyperpolarization-activated Cyclic Nucleotide-gated Channel Pulsed Radiofrequency Neuropathic Pain Chronic Constriction Injury Neuromodulation
刊名JOURNAL OF MOLECULAR NEUROSCIENCE
2015-09-01
DOI10.1007/s12031-015-0582-x
57期:1页:97-105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]PERIPHERAL-NERVE INJURY ; INDUCED TACTILE ALLODYNIA ; HCN2 ION CHANNELS ; CATION CHANNELS ; MECHANICAL ALLODYNIA ; PACEMAKER CHANNELS ; CONTRIBUTES ; HYPERSENSITIVITY ; HYPERALGESIA ; NEURONS
英文摘要

Pulsed radiofrequency (PRF) treatment is a minimally invasive technique with multiple therapeutic applications. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel mediating Ih may regulate neuropathic pain signaling. This study aimed to determine whether PRF suppresses neuropathic pain by altering HCN channel expression in dorsal root ganglion (DRG) neurons. Male Sprague Dawley rats with sciatic nerve chronic constriction injury (CCI) were randomly assigned to PRF (n = 60) and sham control (n = 60) groups, respectively. On postoperative day 7 (D07), PRF or sham treatment was delivered to the proximal sciatic nerve for 8 min. Behavioral tests were performed before surgery (D0), on D07, and on D1, D7, and D14 after PRF or sham treatment. HCN1 and HCN2 expression levels in the DRG were examined by immunohistochemistry and Western blot. The results showed that thermal hyperalgesia, mechano-allodynia, and mechano-hyperalgesia were lower, and DRG expression levels of HCN1 and HCN2 higher, in the PRF group compared with sham control animals (all P < 0.05 at D14). In conclusion, PRF can upregulate HCN channel expression in the DRG of rats with sciatic nerve CCI. How this regulation of Ih in nociceptive afferents contributes to the suppression of neuropathic pain by PRF remains to be determined.

语种英语
WOS记录号WOS:000360073300011
资助机构Peking University People&prime ; s Hospital
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54002
专题北京大学第二临床医学院
北京大学第二临床医学院_麻醉科
作者单位Peking Univ, Peoples Hosp, Pain Med Dept, Beijing 100044, Peoples R China
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GB/T 7714
Liu, Yiming,Feng, Yi,Zhang, Tingjie. Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2015,57(1):97-105.
APA Liu, Yiming,Feng, Yi,&Zhang, Tingjie.(2015).Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain.JOURNAL OF MOLECULAR NEUROSCIENCE,57(1),97-105.
MLA Liu, Yiming,et al."Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain".JOURNAL OF MOLECULAR NEUROSCIENCE 57.1(2015):97-105.
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