IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China
Huang, Xin1,2; Nolte, Ilja3; Gao, Zifen2; Vos, Hans1; Hepkema, Bouke4; Poppema, Sibrand1; van den Berg, Anke1; Diepstra, Arjan1
刊名PLOS ONE
2011-06-10
DOI10.1371/journal.pone.0021152
6期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Bernoulli bursary ; University Medical Center Groningen ; Dutch Cancer Society ; Bernoulli bursary ; University Medical Center Groningen ; Dutch Cancer Society
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CLINICAL CHARACTERISTICS ; DISEASE ; INFECTION ; POPULATION ; TAIWAN ; ADULT ; EBV ; EXPRESSION ; SUBTYPE ; BRAZIL
英文摘要

Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.

Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (<20 y). The median age of the Chinese patients was 9 years younger than that of the Dutch patients (28 y vs. 37 y). In addition, the age distribution between the two populations was strikingly different in both the EBV+ subgroups (p<0.001) and the EBV-subgroups (p = 0.01). The mixed cellularity subtype was almost 3x more frequent amongst the Chinese (p<0.001).

Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.

语种英语
所属项目编号KWF: RUG 2009-4313
资助者Bernoulli bursary ; University Medical Center Groningen ; Dutch Cancer Society ; Bernoulli bursary ; University Medical Center Groningen ; Dutch Cancer Society
WOS记录号WOS:000291612600047
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54007
专题北京大学基础医学院_病理学系
作者单位1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
3.Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Unit Genet Epidemiol & Bioinformat, Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
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GB/T 7714
Huang, Xin,Nolte, Ilja,Gao, Zifen,et al. Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China[J]. PLOS ONE,2011,6(6).
APA Huang, Xin.,Nolte, Ilja.,Gao, Zifen.,Vos, Hans.,Hepkema, Bouke.,...&Diepstra, Arjan.(2011).Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China.PLOS ONE,6(6).
MLA Huang, Xin,et al."Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China".PLOS ONE 6.6(2011).
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