|Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China|
|Huang, Xin1,2; Nolte, Ilja3; Gao, Zifen2; Vos, Hans1; Hepkema, Bouke4; Poppema, Sibrand1; van den Berg, Anke1; Diepstra, Arjan1|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||CLINICAL CHARACTERISTICS ; DISEASE ; INFECTION ; POPULATION ; TAIWAN ; ADULT ; EBV ; EXPRESSION ; SUBTYPE ; BRAZIL|
Background: The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.
Methodology/Principal Findings: 157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV-encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (<20 y). The median age of the Chinese patients was 9 years younger than that of the Dutch patients (28 y vs. 37 y). In addition, the age distribution between the two populations was strikingly different in both the EBV+ subgroups (p<0.001) and the EBV-subgroups (p = 0.01). The mixed cellularity subtype was almost 3x more frequent amongst the Chinese (p<0.001).
Conclusion/Significance: CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV-nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.
|项目编号||KWF: RUG 2009-4313|
|资助机构||Bernoulli bursary ; University Medical Center Groningen ; Dutch Cancer Society|
|作者单位||1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands|
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
3.Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Unit Genet Epidemiol & Bioinformat, Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
|Huang, Xin,Nolte, Ilja,Gao, Zifen,et al. Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China[J]. PLOS ONE,2011,6(6).|
|APA||Huang, Xin.,Nolte, Ilja.,Gao, Zifen.,Vos, Hans.,Hepkema, Bouke.,...&Diepstra, Arjan.(2011).Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China.PLOS ONE,6(6).|
|MLA||Huang, Xin,et al."Epidemiology of Classical Hodgkin Lymphoma and Its Association with Epstein Barr Virus in Northern China".PLOS ONE 6.6(2011).|
|Epidemiology of Clas（184KB）||期刊论文||出版稿||开放获取||CC BY-NC-SA||浏览 请求全文|