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学科主题临床医学
High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma
Wu, Z. L.1,3; Song, Y. Q.1,3; Shi, Y. F.1,2,3; Zhu, J.1,3
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2011-08-01
DOI10.1186/1756-8722-4-31
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]TUMOR MICROENVIRONMENT ; SIGNALING PATHWAYS ; PLUS RITUXIMAB ; CANCER ; ANGIOGENESIS ; CHOP ; TRANSCRIPTION ; CHEMOTHERAPY ; ACTIVATOR ; PROTEINS
英文摘要

Background: The purpose of the study was to investigate the expression and prognostic value of STAT3 in diffuse large B-cell lymphoma (DLBCL).

Methods: Seventy-four DLBCL patients from 2001 to 2007 were reviewed in the study. The STAT3 expression in their tumor tissues was examined using the immunohistochemistry (IHC) method, and evaluated for its association with clinicopathological parameters.

Results: Strong nuclear staining of STAT3 and phosphorylated-STAT3(tyr705) (P-STAT3) were observed in 19 cases (25.7%) and 24 cases (32.4%), respectively, and the expression levels were highly consistent between them (P = 0.001). The high nuclear expression of STAT3 was more frequent in the non-germinal center B cell-like (non-GCB) DLBCL than that in the GCB subtype, but not reaching significance (P < 0.061). The high nuclear expression of STAT3 was found to be correlated with poor overall survival (OS) (P = 0.005). Multivariate Cox regression analysis showed that the STAT3 expression was an independent prognostic factor for DLBCL patients regardless of CHOP or R-CHOP regimen used as the first-line therapy.

Conclusion: STAT3 is more frequently expressed in non-GCB DLBCL than that in GCB subtype, and its strong nuclear expression is correlated with poor OS in DLBCL.

语种英语
WOS记录号WOS:000294334500001
项目编号30973484
资助机构National Science Foundation Committee (NSFC) of China
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54010
专题北京大学临床肿瘤学院_淋巴肿瘤内科
作者单位1.Peking Univ, Sch Oncol, Dept Lymphoma, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
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GB/T 7714
Wu, Z. L.,Song, Y. Q.,Shi, Y. F.,et al. High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma[J]. JOURNAL OF HEMATOLOGY &amp; ONCOLOGY,2011,4.
APA Wu, Z. L.,Song, Y. Q.,Shi, Y. F.,&Zhu, J..(2011).High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma.JOURNAL OF HEMATOLOGY & ONCOLOGY,4.
MLA Wu, Z. L.,et al."High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma".JOURNAL OF HEMATOLOGY & ONCOLOGY 4(2011).
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