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学科主题: 临床医学
题名:
High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma
作者: Wu, Z. L.1,3; Song, Y. Q.1,3; Shi, Y. F.1,2,3; Zhu, J.1,3
刊名: JOURNAL OF HEMATOLOGY & ONCOLOGY
发表日期: 2011-08-01
DOI: 10.1186/1756-8722-4-31
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: TUMOR MICROENVIRONMENT ; SIGNALING PATHWAYS ; PLUS RITUXIMAB ; CANCER ; ANGIOGENESIS ; CHOP ; TRANSCRIPTION ; CHEMOTHERAPY ; ACTIVATOR ; PROTEINS
英文摘要:

Background: The purpose of the study was to investigate the expression and prognostic value of STAT3 in diffuse large B-cell lymphoma (DLBCL).

Methods: Seventy-four DLBCL patients from 2001 to 2007 were reviewed in the study. The STAT3 expression in their tumor tissues was examined using the immunohistochemistry (IHC) method, and evaluated for its association with clinicopathological parameters.

Results: Strong nuclear staining of STAT3 and phosphorylated-STAT3(tyr705) (P-STAT3) were observed in 19 cases (25.7%) and 24 cases (32.4%), respectively, and the expression levels were highly consistent between them (P = 0.001). The high nuclear expression of STAT3 was more frequent in the non-germinal center B cell-like (non-GCB) DLBCL than that in the GCB subtype, but not reaching significance (P < 0.061). The high nuclear expression of STAT3 was found to be correlated with poor overall survival (OS) (P = 0.005). Multivariate Cox regression analysis showed that the STAT3 expression was an independent prognostic factor for DLBCL patients regardless of CHOP or R-CHOP regimen used as the first-line therapy.

Conclusion: STAT3 is more frequently expressed in non-GCB DLBCL than that in GCB subtype, and its strong nuclear expression is correlated with poor OS in DLBCL.

语种: 英语
所属项目编号: 30973484
项目资助者: National Science Foundation Committee (NSFC) of China
WOS记录号: WOS:000294334500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54010
Appears in Collections:北京大学临床肿瘤学院_淋巴肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Lymphoma, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Wu, Z. L.,Song, Y. Q.,Shi, Y. F.,et al. High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma[J]. JOURNAL OF HEMATOLOGY &amp; ONCOLOGY,2011,4.
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