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学科主题: 临床医学
题名:
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
作者: Feng, Yingying1,2,3; Xu, Xiaojie2; Zhang, Yunjing2,4; Ding, Jianhua3; Wang, Yonggang3; Zhang, Xiaopeng5; Wu, Zhe3; Kang, Lei6; Liang, Yingchun2; Zhou, LiYing2; Song, Santai1; Zhao, Ke3; Ye, Qinong2
刊名: SCIENTIFIC REPORTS
发表日期: 2015-03-24
DOI: 10.1038/srep09429
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HOMEOBOX INTERACTING PROTEIN-1 ; MESENCHYMAL TRANSITION ; GROWTH ; RECEPTOR ; PATHWAY ; ACTIVATION ; EXPRESSION ; THERAPY ; NETWORK ; ARREST
英文摘要:

Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer (CRC) is unknown. Here, we report that HPIP is over expressed in most of CRC patients and predicts poor clinical outcome in CRC. HPIP promotes CRC cell proliferation via activation of G1/S and G2/M checkpoint transitions, concomitant with a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. HPIP inhibits CRC cell apoptosis accompanied by the decreased levels of BAX and PIG3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor BCL2. HPIP blocks caspase-3-mediated cleavage of PARP, an important apoptosis marker. HPIP promotes CRC cell migration and invasion, and regulates epithelial-mesenchymal transition (EMT), which plays a critical role in cancer cell migration and invasion. Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell proliferation, migration and EMT. Moreover, HPIP knockdown suppresses colorectal tumor growth in nude mice. These data highlight the important role of HPIP in CRC cell proliferation and progression and suggest that HPIP may be a useful target for CRC therapy.

语种: 英语
所属项目编号: 2011CB504202 ; 2012CB945100 ; 81330053 ; 81272913 ; 81472589 ; 31100604 ; Z141102001814055
项目资助者: China Major State Basic Research Development Program ; National Natural Science Foundation ; Beijing Nova Program
WOS记录号: WOS:000351702000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54020
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing, Peoples R China
3.Acad Mil Med Sci, Affiliated Hosp, Beijing, Peoples R China
4.Second Artillery Gen Hosp, Dept Colorectal Surg, Beijing, Peoples R China
5.Second Artillery Gen Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China
6.Beijing Inst Biotechnol, Lab Vaccine & Antibody Engn, Beijing, Peoples R China

Recommended Citation:
Feng, Yingying,Xu, Xiaojie,Zhang, Yunjing,et al. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion[J]. SCIENTIFIC REPORTS,2015,5.
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