IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科
学科主题临床医学
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
Feng, Yingying1,2,3; Xu, Xiaojie2; Zhang, Yunjing2,4; Ding, Jianhua3; Wang, Yonggang3; Zhang, Xiaopeng5; Wu, Zhe3; Kang, Lei6; Liang, Yingchun2; Zhou, LiYing2; Song, Santai1; Zhao, Ke3; Ye, Qinong2
刊名SCIENTIFIC REPORTS
2015-03-24
DOI10.1038/srep09429
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HOMEOBOX INTERACTING PROTEIN-1 ; MESENCHYMAL TRANSITION ; GROWTH ; RECEPTOR ; PATHWAY ; ACTIVATION ; EXPRESSION ; THERAPY ; NETWORK ; ARREST
英文摘要

Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer (CRC) is unknown. Here, we report that HPIP is over expressed in most of CRC patients and predicts poor clinical outcome in CRC. HPIP promotes CRC cell proliferation via activation of G1/S and G2/M checkpoint transitions, concomitant with a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. HPIP inhibits CRC cell apoptosis accompanied by the decreased levels of BAX and PIG3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor BCL2. HPIP blocks caspase-3-mediated cleavage of PARP, an important apoptosis marker. HPIP promotes CRC cell migration and invasion, and regulates epithelial-mesenchymal transition (EMT), which plays a critical role in cancer cell migration and invasion. Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell proliferation, migration and EMT. Moreover, HPIP knockdown suppresses colorectal tumor growth in nude mice. These data highlight the important role of HPIP in CRC cell proliferation and progression and suggest that HPIP may be a useful target for CRC therapy.

语种英语
WOS记录号WOS:000351702000001
项目编号2011CB504202 ; 2012CB945100 ; 81330053 ; 81272913 ; 81472589 ; 31100604 ; Z141102001814055
资助机构China Major State Basic Research Development Program ; National Natural Science Foundation ; Beijing Nova Program
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54020
专题北京大学第一临床医学院_核医学科
作者单位1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing, Peoples R China
3.Acad Mil Med Sci, Affiliated Hosp, Beijing, Peoples R China
4.Second Artillery Gen Hosp, Dept Colorectal Surg, Beijing, Peoples R China
5.Second Artillery Gen Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China
6.Beijing Inst Biotechnol, Lab Vaccine & Antibody Engn, Beijing, Peoples R China
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GB/T 7714
Feng, Yingying,Xu, Xiaojie,Zhang, Yunjing,et al. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion[J]. SCIENTIFIC REPORTS,2015,5.
APA Feng, Yingying.,Xu, Xiaojie.,Zhang, Yunjing.,Ding, Jianhua.,Wang, Yonggang.,...&Ye, Qinong.(2015).HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion.SCIENTIFIC REPORTS,5.
MLA Feng, Yingying,et al."HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion".SCIENTIFIC REPORTS 5(2015).
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