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学科主题: 临床医学
题名:
Relationship between angiotensin-converting enzyme gene insertion or deletion polymorphism and insulin sensitivity in healthy newborns
作者: Han, Tongyan; Wang, Xinli; Cui, Yunpu; Ye, Hongmao; Tong, Xiaomei; Piao, Meihua
关键词: ACE gene insertion/deletion polymorphism ; D allele ; healthy newborns ; insulin sensitivity
刊名: PEDIATRICS
发表日期: 2007-06-01
DOI: 10.1542/peds.2006-3297
卷: 119, 期:6, 页:1089-1094
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: DEPENDENT DIABETES-MELLITUS ; MYOCARDIAL-INFARCTION ; RESISTANCE ; GLUCOSE ; DISEASE ; GROWTH ; HYPERINSULINEMIA ; RESPONSIVENESS ; ASSOCIATION ; HYPOTHESIS
英文摘要:

Context. It was proposed that the association between low birth weight and adult insulin resistance is principally genetically mediated. The insertion/deletion polymorphism of the angiotensin-converting enzyme gene was associated with insulin sensitivity in adults.

Objective. Our goal was to investigate the relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and the insulin sensitivity in healthy newborns.

Patients and Methods. One hundred eighty healthy newborns, all of whom had a 1-minute Apgar score of >7 and gestational age >33 weeks, were enrolled in the study. Fasting glucose and insulin levels were measured on day 2 or 3 after birth, and angiotensin-converting enzyme genotype was determined.

Results. The observed frequency distribution of angiotensin-converting enzyme genotypes did not deviate from that predicted by Hardy-Weinberg equilibrium in this group. There were no statistically significant differences in birth size and shape in different angiotensin-converting enzyme genotypes. Those carriers of the genotype homozygous for the deletion allele had the highest logarithmically transformed homeostasis model assessment compared with those who were heterozygous or homozygous for the insertion polymorphism. When compared with those with >= 1 insertion allele, those of the genotype homozygous for the deletion allele had significantly higher logarithmically transformed fasting insulin and logarithmically transformed homeostasis model assessment results. Regarding birth weight, birth length, ponderal index, and fasting glucose concentration, there were no significant differences between the genotype homozygous for the deletion allele and the genotypes heterozygous or homozygous for the insertion allele.

Conclusions. In this study, the deletion allele was associated with relatively impaired insulin sensitivity in healthy neonates. It may be a clue to explain the association between the deletion allele and insulin resistance in the long-term.

语种: 英语
WOS记录号: WOS:000246948900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54024
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Pediat, Beijing 100083, Peoples R China

Recommended Citation:
Han, Tongyan,Wang, Xinli,Cui, Yunpu,et al. Relationship between angiotensin-converting enzyme gene insertion or deletion polymorphism and insulin sensitivity in healthy newborns[J]. PEDIATRICS,2007,119(6):1089-1094.
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