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学科主题: 临床医学
题名:
Association of a mutation in the beta(3)-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children
作者: Xinli, W; Xiaomei, T; Meihua, P; Song, L
关键词: beta(3)-adrenergic receptor gene ; children ; dietary intervention ; obesity
刊名: ACTA PAEDIATRICA
发表日期: 2001-11-01
卷: 90, 期:11, 页:1233-1237
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: BASAL METABOLIC-RATE ; UNCOUPLING PROTEIN-1 ; WEIGHT-LOSS ; INSULIN-RESISTANCE ; TRP64ARG MUTATION ; POLYMORPHISM ; TISSUE ; FINNS ; MICE
英文摘要:

This study aimed to determine whether the Trp64Arg mutation in the beta (3)-adrenergic receptor (beta (3)-adr) gene is related to childhood obesity and the response to dietary intervention for obesity. The study included 311 healthy children aged 8-11 y selected at random from 4 primary schools in Beijing. Fasting insulin and lipids were measured and anthropometry was carried out for all samples. The mutation of the beta (3)-adr gene was determined by polymerase chain reaction-restriction fragment length poly morphism analysis. Forty-seven obese children were selected and divided into two groups. One group received dietary intervention (36 subjects); the other served as the control group (I I Subjects). After 3 mo of dietary intervention, anthropometry was carried out again in 47 obese children. The frequency of the mutated allele was similar in 73 overweight and 238 normal-weight children (0.18 and 0.17, respectively). Adjusted for age and sex, there was no significant difference in body mass index (BMI) and the levels of fasting lipids and insulin between those with and without the mutation of the 311 children. However, after 3 mo of dietary intervention, increases in weight and BMI were significantly lower in obese children without the mutation than in the control group (2.41 +/- 0.56 vs 4.43 +/- 0.70, p < 0.05: 0.48 +/- 0.24 vs 1.55 +/- 0,35, p < 0.05, respectively), but the changes in weight and BMI in obese children with the mutation were similar to the results in the controls (4.32 +/- 0.69 vs 4.43 +/- 0.70; 1.47 +/- 0.32 vs 1.55 +/- 0.35).

Conclusion: The Trp64Arg mutation of the beta (3)-adr gene may predict the result of dietary intervention in obese children to some extent, but it was not a major factor affecting weight in Chinese children.

语种: 英语
WOS记录号: WOS:000172785300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54025
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Pediat, Beijing 100083, Peoples R China

Recommended Citation:
Xinli, W,Xiaomei, T,Meihua, P,et al. Association of a mutation in the beta(3)-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children[J]. ACTA PAEDIATRICA,2001,90(11):1233-1237.
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