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Microbial transformation of cinobufagin by Syncephalastrum racemosum
Ma, Xiao-chi1,2; Xin, Xiu-lan1,3; Liu, Ke-xin2; Han, Jian1; Guo, De-an1
刊名JOURNAL OF NATURAL PRODUCTS
2008-07-01
DOI10.1021/np800210a
71期:7页:1268-1270
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]CYTOTOXIC BUFADIENOLIDES ; MUCOR-SPINOSUS ; BUFALIN ; CELLS ; HYDROXYLATION
英文摘要

Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7 beta-hydroxycinobufagin (2), 12 beta-hydroxycinobufagin (3), cinobufotalin (4), 5,12 beta-dihydroxycinobufagin (5), 4 beta, 11 alpha-dihydroxycinobufagin (6), and 4 beta, 12 alpha-dihydroxycinobufagin (7), respectively, on the basis of spectroscopic studies. Metabolites 2 and 5-7 were characterized as new compounds, and 2-7 proved to be cytotoxic against Bel-7402 human hepatoma cells.

语种英语
WOS记录号WOS:000257953800030
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54026
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimetr Drugs, Beijing 100083, Peoples R China
2.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
3.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiao-chi,Xin, Xiu-lan,Liu, Ke-xin,et al. Microbial transformation of cinobufagin by Syncephalastrum racemosum[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(7):1268-1270.
APA Ma, Xiao-chi,Xin, Xiu-lan,Liu, Ke-xin,Han, Jian,&Guo, De-an.(2008).Microbial transformation of cinobufagin by Syncephalastrum racemosum.JOURNAL OF NATURAL PRODUCTS,71(7),1268-1270.
MLA Ma, Xiao-chi,et al."Microbial transformation of cinobufagin by Syncephalastrum racemosum".JOURNAL OF NATURAL PRODUCTS 71.7(2008):1268-1270.
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