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学科主题: 药学
题名:
Microbial transformation of cinobufagin by Syncephalastrum racemosum
作者: Ma, Xiao-chi1,2; Xin, Xiu-lan1,3; Liu, Ke-xin2; Han, Jian1; Guo, De-an1
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2008-07-01
DOI: 10.1021/np800210a
卷: 71, 期:7, 页:1268-1270
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: CYTOTOXIC BUFADIENOLIDES ; MUCOR-SPINOSUS ; BUFALIN ; CELLS ; HYDROXYLATION
英文摘要:

Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7 beta-hydroxycinobufagin (2), 12 beta-hydroxycinobufagin (3), cinobufotalin (4), 5,12 beta-dihydroxycinobufagin (5), 4 beta, 11 alpha-dihydroxycinobufagin (6), and 4 beta, 12 alpha-dihydroxycinobufagin (7), respectively, on the basis of spectroscopic studies. Metabolites 2 and 5-7 were characterized as new compounds, and 2-7 proved to be cytotoxic against Bel-7402 human hepatoma cells.

语种: 英语
WOS记录号: WOS:000257953800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54026
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimetr Drugs, Beijing 100083, Peoples R China
2.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
3.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China

Recommended Citation:
Ma, Xiao-chi,Xin, Xiu-lan,Liu, Ke-xin,et al. Microbial transformation of cinobufagin by Syncephalastrum racemosum[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(7):1268-1270.
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