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学科主题: 基础医学
题名:
Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis
作者: Wang, Yutang1; Wen, Yunyi1; Fang, Yan1; Pang, Huan1; Guo, Zhirong2; Shi, Lei1; Li, Junfa3
关键词: Erythrocyte-derived depressing factor ; Arterial calcinosis ; Vascular reactivity ; Ca(2+)-ATPase ; Cell cycle
刊名: VASCULAR PHARMACOLOGY
发表日期: 2009
DOI: 10.1016/j.vph.2008.10.001
卷: 50, 期:1-2, 页:65-70
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: VASCULAR SMOOTH-MUSCLE ; SPONTANEOUSLY HYPERTENSIVE RATS ; CALCIUM-ENTRY BLOCKER ; PROTECTIVE ROLE ; BLOOD-PRESSURE ; ACTIVATION ; CELLS ; PHOSPHORYLATION ; OVERLOAD ; PROLIFERATION
英文摘要:

Erythrocyte-derived depressing factor (EDDF) shows significant protective effects on blood vessels from hypertensive rats, by regulating vascular reactivity, calcium homeostasis, DNA synthesis, and cell cycle progression in vascular smooth Muscles (VSMCs). Arteries from hypertensive and aging people have high levels of accumulated calcium. However, in the life span of experimental animals commonly used, arterial calcium content does not reach cytotoxic levels observed in human. An overdose of vitamin D(3) results in a rapid arterial calcium overload. Using rats with arterial calcinosis and age- and gender-matched Wistar controls, we investigated whether EDDF has beneficial effect on blood vessels from animals with arterial calcinosis. Blood vessel functions were impaired in rats with arterial calcinosis, as indicated by decreased Ca(2+)-ATPase activity, increased vasoconstrictor responses to alphal adrenoceptor agonist phenylephrine and increased ERK1/2 phosphorylation. Arterial calcium overload also impaired the morphological integrity of VSMCs. EDDF restored the abovementioned abnormalities caused by arterial calcinosis, and inhibited cell cycle progression of VSMCs induced by angiotensin II.

In conclusion, EDDF may protect blood vessels from animals with arterial calcinosis, which is mediated by regulating calcium homeostasis, vascular reactivity and cell cycle progression as well as by improving morphological integrity of VSMCs. (c) 2008 Elsevier Inc All rights reserved.

语种: 英语
所属项目编号: 30570723
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000262326300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54027
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, Beijing 100005, Peoples R China
2.Peking Univ Beijing, Sch Basic Med, Dept Pathogen Biol, Beijing, Peoples R China
3.Capital Med Univ, Dept Neurobiol, Inst Biomed Sci Pain, Beijing, Peoples R China

Recommended Citation:
Wang, Yutang,Wen, Yunyi,Fang, Yan,et al. Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis[J]. VASCULAR PHARMACOLOGY,2009,50(1-2):65-70.
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