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学科主题基础医学
Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis
Wang, Yutang1; Wen, Yunyi1; Fang, Yan1; Pang, Huan1; Guo, Zhirong2; Shi, Lei1; Li, Junfa3
关键词Erythrocyte-derived Depressing Factor Arterial Calcinosis Vascular Reactivity Ca(2+)-atpase Cell Cycle
刊名VASCULAR PHARMACOLOGY
2009
DOI10.1016/j.vph.2008.10.001
50期:1-2页:65-70
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]VASCULAR SMOOTH-MUSCLE ; SPONTANEOUSLY HYPERTENSIVE RATS ; CALCIUM-ENTRY BLOCKER ; PROTECTIVE ROLE ; BLOOD-PRESSURE ; ACTIVATION ; CELLS ; PHOSPHORYLATION ; OVERLOAD ; PROLIFERATION
英文摘要

Erythrocyte-derived depressing factor (EDDF) shows significant protective effects on blood vessels from hypertensive rats, by regulating vascular reactivity, calcium homeostasis, DNA synthesis, and cell cycle progression in vascular smooth Muscles (VSMCs). Arteries from hypertensive and aging people have high levels of accumulated calcium. However, in the life span of experimental animals commonly used, arterial calcium content does not reach cytotoxic levels observed in human. An overdose of vitamin D(3) results in a rapid arterial calcium overload. Using rats with arterial calcinosis and age- and gender-matched Wistar controls, we investigated whether EDDF has beneficial effect on blood vessels from animals with arterial calcinosis. Blood vessel functions were impaired in rats with arterial calcinosis, as indicated by decreased Ca(2+)-ATPase activity, increased vasoconstrictor responses to alphal adrenoceptor agonist phenylephrine and increased ERK1/2 phosphorylation. Arterial calcium overload also impaired the morphological integrity of VSMCs. EDDF restored the abovementioned abnormalities caused by arterial calcinosis, and inhibited cell cycle progression of VSMCs induced by angiotensin II.

In conclusion, EDDF may protect blood vessels from animals with arterial calcinosis, which is mediated by regulating calcium homeostasis, vascular reactivity and cell cycle progression as well as by improving morphological integrity of VSMCs. (c) 2008 Elsevier Inc All rights reserved.

语种英语
所属项目编号30570723
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
WOS记录号WOS:000262326300011
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54027
专题北京大学基础医学院
作者单位1.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, Beijing 100005, Peoples R China
2.Peking Univ Beijing, Sch Basic Med, Dept Pathogen Biol, Beijing, Peoples R China
3.Capital Med Univ, Dept Neurobiol, Inst Biomed Sci Pain, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yutang,Wen, Yunyi,Fang, Yan,et al. Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis[J]. VASCULAR PHARMACOLOGY,2009,50(1-2):65-70.
APA Wang, Yutang.,Wen, Yunyi.,Fang, Yan.,Pang, Huan.,Guo, Zhirong.,...&Li, Junfa.(2009).Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis.VASCULAR PHARMACOLOGY,50(1-2),65-70.
MLA Wang, Yutang,et al."Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis".VASCULAR PHARMACOLOGY 50.1-2(2009):65-70.
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