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学科主题临床医学
Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial
Zhang, L; Ma, JL; Pan, KF; Go, VLW; Chen, JS; You, WC
关键词Intervention Helicobacter Pylori Cranberry Juice Clinical Trial
刊名HELICOBACTER
2005-04-01
10期:2页:139-145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]Gastroenterology & Hepatology ; Microbiology
关键词[WOS]PRECANCEROUS GASTRIC-LESIONS ; URINARY-TRACT HEALTH ; HIGH-RISK ; STOMACH-CANCER ; VITAMIN-C ; CHINESE POPULATION ; BREATH TEST ; ERADICATION ; PROGRESSION ; DIAGNOSIS
英文摘要

Background. Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. This study postulated that cranberry juice would be effective in the suppression of H. pylori in an endemically infected population at high risk for gastric cancer.

Materials and methods. A prospective, randomized, double-blind, placebo-controlled trial was conducted in Linqu County of Shandong Province, China, where 189 adults aged 48.9 +/- 11.2 years (mean +/- SD) with H. pylori infection were randomly divided into two groups: cranberry juice (n = 97) and placebo (n = 92). Participants were assigned to orally receive two 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days. The degree of H. pylori infection was determined using the C-13-urea breath test before randomization at 35 and 90 days of intervention to assess the efficacy of cranberry juice in alleviating infection.

Results. A total of 189 subjects with positive C-13-urea breath test results prior to randomization completed the study. At day 35 of intervention, 14 of the 97 (14.43%) from the the cranberry juice treatment group and 5 of the 92 (5.44%) of the placebo recipients had negative C-13-urea breath test results. After 90 days, the study concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results. Eleven individuals from the cranberry juice treatment group and only two from the placebo group were negative at 35 and 90 days of experiment. These results are significant (p < .05).

Conclusions. Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations.

语种英语
WOS记录号WOS:000227593200007
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54029
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
2.Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA
推荐引用方式
GB/T 7714
Zhang, L,Ma, JL,Pan, KF,et al. Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial[J]. HELICOBACTER,2005,10(2):139-145.
APA Zhang, L,Ma, JL,Pan, KF,Go, VLW,Chen, JS,&You, WC.(2005).Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial.HELICOBACTER,10(2),139-145.
MLA Zhang, L,et al."Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial".HELICOBACTER 10.2(2005):139-145.
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