|Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial|
|Zhang, L; Ma, JL; Pan, KF; Go, VLW; Chen, JS; You, WC|
|关键词||Intervention Helicobacter Pylori Cranberry Juice Clinical Trial|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology ; Microbiology|
|研究领域[WOS]||Gastroenterology & Hepatology ; Microbiology|
|关键词[WOS]||PRECANCEROUS GASTRIC-LESIONS ; URINARY-TRACT HEALTH ; HIGH-RISK ; STOMACH-CANCER ; VITAMIN-C ; CHINESE POPULATION ; BREATH TEST ; ERADICATION ; PROGRESSION ; DIAGNOSIS|
Background. Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. This study postulated that cranberry juice would be effective in the suppression of H. pylori in an endemically infected population at high risk for gastric cancer.
Materials and methods. A prospective, randomized, double-blind, placebo-controlled trial was conducted in Linqu County of Shandong Province, China, where 189 adults aged 48.9 +/- 11.2 years (mean +/- SD) with H. pylori infection were randomly divided into two groups: cranberry juice (n = 97) and placebo (n = 92). Participants were assigned to orally receive two 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days. The degree of H. pylori infection was determined using the C-13-urea breath test before randomization at 35 and 90 days of intervention to assess the efficacy of cranberry juice in alleviating infection.
Results. A total of 189 subjects with positive C-13-urea breath test results prior to randomization completed the study. At day 35 of intervention, 14 of the 97 (14.43%) from the the cranberry juice treatment group and 5 of the 92 (5.44%) of the placebo recipients had negative C-13-urea breath test results. After 90 days, the study concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results. Eleven individuals from the cranberry juice treatment group and only two from the placebo group were negative at 35 and 90 days of experiment. These results are significant (p < .05).
Conclusions. Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations.
|作者单位||1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China|
2.Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA
|Zhang, L,Ma, JL,Pan, KF,et al. Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial[J]. HELICOBACTER,2005,10(2):139-145.|
|APA||Zhang, L,Ma, JL,Pan, KF,Go, VLW,Chen, JS,&You, WC.(2005).Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial.HELICOBACTER,10(2),139-145.|
|MLA||Zhang, L,et al."Efficacy of cranberry juice on Helicobacter pylori infection: A double-blind, randomized placebo-controlled trial".HELICOBACTER 10.2(2005):139-145.|