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学科主题药学
Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate
Zhou, Shouxin1; Tian, Chao1; Li, Chao1; Guo, Ying1; Wang, Xiaowei1; Liu, Junyi1,2; Zhang, Zhili1
关键词Tetrahydrofolate Aziridine Catalytic Hydrogenation Solvent-free
刊名MOLECULES
2012-05-01
DOI10.3390/molecules17055604
17期:5页:5604-5614
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Science Foundation of China ; Ministry of Science and Technology of China ; National Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Chemistry
关键词[WOS]GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE ; BIOLOGICAL EVALUATION ; ANTITUMOR-ACTIVITY ; ACID ; INHIBITORS ; AGENTS ; DERIVATIVES ; SYNTHETASE ; ANTIFOLATE ; AMINES
英文摘要

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this method, the byproducts of carbon-nitrogen bond hydrogenolysis in traditional synthetic strategy can be completely avoided.

语种英语
所属项目编号20972011 ; 21042009 ; 21172014 ; 2009ZX09301-010
资助者National Science Foundation of China ; Ministry of Science and Technology of China ; National Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000304587600065
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54030
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Shouxin,Tian, Chao,Li, Chao,et al. Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate[J]. MOLECULES,2012,17(5):5604-5614.
APA Zhou, Shouxin.,Tian, Chao.,Li, Chao.,Guo, Ying.,Wang, Xiaowei.,...&Zhang, Zhili.(2012).Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate.MOLECULES,17(5),5604-5614.
MLA Zhou, Shouxin,et al."Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate".MOLECULES 17.5(2012):5604-5614.
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