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学科主题: 药学
题名:
Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate
作者: Zhou, Shouxin1; Tian, Chao1; Li, Chao1; Guo, Ying1; Wang, Xiaowei1; Liu, Junyi1,2; Zhang, Zhili1
关键词: tetrahydrofolate ; aziridine ; catalytic hydrogenation ; solvent-free
刊名: MOLECULES
发表日期: 2012-05-01
DOI: 10.3390/molecules17055604
卷: 17, 期:5, 页:5604-5614
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE ; BIOLOGICAL EVALUATION ; ANTITUMOR-ACTIVITY ; ACID ; INHIBITORS ; AGENTS ; DERIVATIVES ; SYNTHETASE ; ANTIFOLATE ; AMINES
英文摘要:

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this method, the byproducts of carbon-nitrogen bond hydrogenolysis in traditional synthetic strategy can be completely avoided.

语种: 英语
所属项目编号: 20972011 ; 21042009 ; 21172014 ; 2009ZX09301-010
项目资助者: National Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000304587600065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54030
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Shouxin,Tian, Chao,Li, Chao,et al. Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate[J]. MOLECULES,2012,17(5):5604-5614.
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