IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers
Liu, Yu1,2; Bao, Yan-ping2; Sun, Hong-qiang2,3; Beveridge, Thomas J. R.4; Li, Su-xia2; Di, Xiao-lan3; Yang, Fu-de3; Lu, Lin2
关键词Nicotine Dependence Aripiprazole Waking And postprAndial Urge To Smoke Heavy Smokers Dopamine Partial Agonist
刊名JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2010-08-01
DOI10.1097/JCP.0b013e3181e78a2b
30期:4页:373-380
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
资助者Program for New Century Excellent Talents in University ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; Program for New Century Excellent Talents in University ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program)
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NICOTINE REPLACEMENT THERAPY ; DOPAMINE-RECEPTOR AGONISTS ; D-AMPHETAMINE ; WITHDRAWAL SYMPTOMS ; TOBACCO WITHDRAWAL ; BLOCKS REINSTATEMENT ; ALCOHOL DEPENDENCE ; COCAINE-SEEKING ; 1ST CIGARETTE ; ANIMAL-MODEL
英文摘要

The central dopaminergic system plays a critical role in the reinforcing effects of nicotine, which are key determinants in the urge to smoke. Previous study has demonstrated that immediate administration of 10-mg aripiprazole significantly decreased various subjective responses to smoking. The present study investigated whether 2-week treatment with 10-mg aripiprazole could attenuate waking and postprandial urges to smoke in Chinese male and female heavy smokers. A randomized and placebo-controlled pilot clinical study was conducted to assess the effect of aripiprazole on various responses to smoking. The primary outcomes were subject′s ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. All participants were administered either placebo or 10-mg aripiprazole for 2 weeks. Throughout the experiment, participants were required to self-report (1) smoking urge and nicotine withdrawal symptoms before their first cigarette after awakening and after lunch and (2) subjective responses to the first cigarette smoked of the day and after lunch. Aripiprazole was associated with significantly decreased waking and postprandial urges to smoke. Aripiprazole failed to produce a significant effect on overall nicotine withdrawal symptoms after awakening and after lunch. However, waking, but not postprandial, withdrawal craving and syndromes were significantly reduced by aripiprazole. Aripiprazole had no effect on the overall subjective responses to the first cigarette of the day and after lunch. The attenuating effects of aripiprazole on waking and postprandial urges to smoke demonstrate the promising effect of aripiprazole in the treatment of nicotine dependence.

语种英语
所属项目编号2007CB512302 ; 2006AA02Z4D1
资助者Program for New Century Excellent Talents in University ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program) ; Program for New Century Excellent Talents in University ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program)
WOS记录号WOS:000279900700005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54034
专题中国药物依赖性研究所
作者单位1.Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Beijing Huilongguan Hosp, Dept Alcohol Dependence, Beijing, Peoples R China
4.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA
推荐引用方式
GB/T 7714
Liu, Yu,Bao, Yan-ping,Sun, Hong-qiang,et al. Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2010,30(4):373-380.
APA Liu, Yu.,Bao, Yan-ping.,Sun, Hong-qiang.,Beveridge, Thomas J. R..,Li, Su-xia.,...&Lu, Lin.(2010).Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,30(4),373-380.
MLA Liu, Yu,et al."Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 30.4(2010):373-380.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Yu]的文章
[Bao, Yan-ping]的文章
[Sun, Hong-qiang]的文章
百度学术
百度学术中相似的文章
[Liu, Yu]的文章
[Bao, Yan-ping]的文章
[Sun, Hong-qiang]的文章
必应学术
必应学术中相似的文章
[Liu, Yu]的文章
[Bao, Yan-ping]的文章
[Sun, Hong-qiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。