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学科主题: 药物依赖
题名:
Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers
作者: Liu, Yu1,2; Bao, Yan-ping2; Sun, Hong-qiang2,3; Beveridge, Thomas J. R.4; Li, Su-xia2; Di, Xiao-lan3; Yang, Fu-de3; Lu, Lin2
关键词: nicotine dependence ; aripiprazole ; waking and postprandial urge to smoke ; heavy smokers ; dopamine partial agonist
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2010-08-01
DOI: 10.1097/JCP.0b013e3181e78a2b
卷: 30, 期:4, 页:373-380
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NICOTINE REPLACEMENT THERAPY ; DOPAMINE-RECEPTOR AGONISTS ; D-AMPHETAMINE ; WITHDRAWAL SYMPTOMS ; TOBACCO WITHDRAWAL ; BLOCKS REINSTATEMENT ; ALCOHOL DEPENDENCE ; COCAINE-SEEKING ; 1ST CIGARETTE ; ANIMAL-MODEL
英文摘要:

The central dopaminergic system plays a critical role in the reinforcing effects of nicotine, which are key determinants in the urge to smoke. Previous study has demonstrated that immediate administration of 10-mg aripiprazole significantly decreased various subjective responses to smoking. The present study investigated whether 2-week treatment with 10-mg aripiprazole could attenuate waking and postprandial urges to smoke in Chinese male and female heavy smokers. A randomized and placebo-controlled pilot clinical study was conducted to assess the effect of aripiprazole on various responses to smoking. The primary outcomes were subject′s ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. All participants were administered either placebo or 10-mg aripiprazole for 2 weeks. Throughout the experiment, participants were required to self-report (1) smoking urge and nicotine withdrawal symptoms before their first cigarette after awakening and after lunch and (2) subjective responses to the first cigarette smoked of the day and after lunch. Aripiprazole was associated with significantly decreased waking and postprandial urges to smoke. Aripiprazole failed to produce a significant effect on overall nicotine withdrawal symptoms after awakening and after lunch. However, waking, but not postprandial, withdrawal craving and syndromes were significantly reduced by aripiprazole. Aripiprazole had no effect on the overall subjective responses to the first cigarette of the day and after lunch. The attenuating effects of aripiprazole on waking and postprandial urges to smoke demonstrate the promising effect of aripiprazole in the treatment of nicotine dependence.

语种: 英语
所属项目编号: 2007CB512302 ; 2006AA02Z4D1
项目资助者: Program for New Century Excellent Talents in University ; National Basic Research Program of China (973 Program) ; National High Technology Research and Development Program of China (863 Program)
WOS记录号: WOS:000279900700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54034
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Beijing Huilongguan Hosp, Dept Alcohol Dependence, Beijing, Peoples R China
4.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA

Recommended Citation:
Liu, Yu,Bao, Yan-ping,Sun, Hong-qiang,et al. Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2010,30(4):373-380.
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