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Myosin Vb gene is associated with schizophrenia in Chinese Han population
Chen, Yaguang1,2; Tian, Lin1,2; Zhang, Fuquan1,2; Liu, Chenxing1,2; Lu, Tianlan1,2; Ruan, Yanyan1,2; Wang, Lifang1,2; Yan, Hao1,2; Yan, Jun1,2; Liu, Qi1,2; Zhang, Hongyan1,2; Ma, WenBin7; Yang, JianLi6; Li, KeQing5; Lv, LuXian3,4; Zhang, Dai1,2,8,9; Yue, Weihua1,2
关键词Ampa Receptor Glutamate Bipolar Disorder Genetic Association Polymorphism
刊名PSYCHIATRY RESEARCH
2013-05-15
DOI10.1016/j.psychres.2013.02.026
207期:1-2页:13-18
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者National Basic Research Program of China ; National Science and Technology Project ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Science and Technology Project ; National Natural Science Foundation of China
研究领域[WOS]Psychiatry
关键词[WOS]GENOME-WIDE ASSOCIATION ; BIPOLAR DISORDER ; GLUTAMATE HYPOTHESIS ; AMPA RECEPTORS ; EXPRESSION ; DISEASE ; LINKAGE ; VISUALIZATION ; METAANALYSIS ; BRAIN
英文摘要

Myosin Vb (MYO5B) has recently been implicated in the etiology of bipolar disorder in a genome-wide association study (GWAS). This gene is involved in amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit glutamate receptor 1 (GluR1) recycling and plays an important role in the primary excitatory neurotransmission. Dysfunction of the brain glutamate system has been postulated to be involved in the pathophysiology in schizophrenia. To further investigate the association between MYO5B polymorphisms and schizophrenia, we genotyped nine single nucleotide polymorphisms (SNPs) in an independent sample of 1463 individuals with schizophrenia and 1563 healthy control subjects, and detected three SNPs and two haplotype blocks which displayed significant association with schizophrenia. This association was further strengthened by the results of meta-analysis. Our data strongly supported that the MYO5B gene might be associated with schizophrenia in the Chinese Han population and they have implications for understanding the glutamate hypothesis of schizophrenia. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2011CB707805 ; 2012BAI01B06 ; 81222017 ; 91232305
资助者National Basic Research Program of China ; National Science and Technology Project ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Science and Technology Project ; National Natural Science Foundation of China
WOS记录号WOS:000319184100002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54037
专题北京大学精神卫生研究所
作者单位1.Tianjin Anding Hosp Tianjin Municipal, Tianjin, Peoples R China
2.Jinzhou Kangning Hosp, Jinzhou, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Hebei Mental Hlth Ctr, Baoding, Peoples R China
5.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
6.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
7.Xinxiang Med Univ, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Peoples R China
8.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
9.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yaguang,Tian, Lin,Zhang, Fuquan,et al. Myosin Vb gene is associated with schizophrenia in Chinese Han population[J]. PSYCHIATRY RESEARCH,2013,207(1-2):13-18.
APA Chen, Yaguang.,Tian, Lin.,Zhang, Fuquan.,Liu, Chenxing.,Lu, Tianlan.,...&Yue, Weihua.(2013).Myosin Vb gene is associated with schizophrenia in Chinese Han population.PSYCHIATRY RESEARCH,207(1-2),13-18.
MLA Chen, Yaguang,et al."Myosin Vb gene is associated with schizophrenia in Chinese Han population".PSYCHIATRY RESEARCH 207.1-2(2013):13-18.
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