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学科主题基础医学
Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response
Cheng, Wei2,3; Yang, Fan3,4; Liu, Shuang1; Colton, Craig K.5; Wang, Chunbo5; Cui, Yuanyuan1,3; Cao, Xu1,3; Zhu, Michael X.6; Sun, Changsen2; Wang, KeWei1; Zheng, Jie3
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2012-03-02
DOI10.1074/jbc.M111.305045
287期:10页:7279-7288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ROOT GANGLION NEURONS ; CAPSAICIN RECEPTOR ; TRP CHANNELS ; ION CHANNELS ; ANKYRIN REPEAT ; MICE LACKING ; THERMOSENSATION ; ACTIVATION ; PAIN ; EXPRESSION
英文摘要

TRPV1 and TRPV3 are two heat-sensitive ion channels activated at distinct temperature ranges perceived by human as hot and warm, respectively. Compounds eliciting human sensations of heat or warmth can also potently activate these channels. In rodents, TRPV3 is expressed predominantly in skin keratinocytes, whereas in humans TRPV1 and TRPV3 are co-expressed in sensory neurons of dorsal root ganglia and trigeminal ganglion and are known to form heteromeric channels with distinct single channel conductances as well as sensitivities to TRPV1 activator capsaicin and inhibitor capsazepine. However, how heteromeric TRPV1/TRPV3 channels respond to heat and other stimuli remains unknown. In this study, we examined the behavior of heteromeric TRPV1/TRPV3 channels activated by heat, capsaicin, and voltage. Our results demonstrate that the heteromeric channels exhibit distinct temperature sensitivity, activation threshold, and heat-induced sensitization. Changes in gating properties apparently originate from interactions between TRPV1 and TRPV3 subunits. Our results suggest that heteromeric TRPV1/TRPV3 channels are unique heat sensors that may contribute to the fine-tuning of sensitivity to sensory inputs.

语种英语
WOS记录号WOS:000301060200030
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/54038
专题北京大学基础医学院_神经生物学系
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Dalian Univ Technol, Coll Phys & Optoelect Engn, Lab Biomed Opt, Dalian 116023, Peoples R China
3.Univ Calif Davis, Dept Physiol & Membrane Biol, Davis, CA 95616 USA
4.Univ Calif Davis, Mol Cellular & Integrat Physiol Grad Grp, Davis, CA 95616 USA
5.Ohio State Univ, Ctr Mol Neurobiol, Columbus, OH 43210 USA
6.Univ Texas Hlth Sci Ctr, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
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GB/T 7714
Cheng, Wei,Yang, Fan,Liu, Shuang,et al. Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2012,287(10):7279-7288.
APA Cheng, Wei.,Yang, Fan.,Liu, Shuang.,Colton, Craig K..,Wang, Chunbo.,...&Zheng, Jie.(2012).Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response.JOURNAL OF BIOLOGICAL CHEMISTRY,287(10),7279-7288.
MLA Cheng, Wei,et al."Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response".JOURNAL OF BIOLOGICAL CHEMISTRY 287.10(2012):7279-7288.
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