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学科主题: 临床医学
题名:
Short-Term Rosuvastatin Therapy for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Diabetes and Chronic Kidney Disease
作者: Han, Yaling1; Zhu, Guoying2; Han, Lixian3; Hou, Fengxia4; Huang, Weijian5; Liu, Huiliang6; Gan, Jihong7; Jiang, Tiemin8; Li, Xiaoyan9; Wang, Wei10; Ding, Shifang11; Jia, Shaobin12; Shen, Weifeng13; Wang, Dongmei14; Sun, Ling15; Qiu, Jian16; Wang, Xiaozeng1; Li, Yi1; Deng, Jie1; Li, Jing1; Xu, Kai1; Xu, Bo17; Mehran, Roxana18; Huo, Yong19
关键词: angiography ; contrast medium ; diabetes mellitus ; kidney ; statins
刊名: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
发表日期: 2014-01-07
DOI: 10.1016/j.jacc.2013.09.017
卷: 63, 期:1, 页:62-70
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERCUTANEOUS CORONARY INTERVENTION ; C-REACTIVE PROTEIN ; INDUCED NEPHROPATHY ; STATIN THERAPY ; CARDIOTHORACIC SURGERY ; SERUM CREATININE ; TRIAL ; RISK ; ATORVASTATIN ; PRETREATMENT
英文摘要:

Objectives This study sought to evaluate the safety and efficacy of rosuvastatin in preventing contrast-induced acute kidney injury (CI-AKI) in patients with diabetes mellitus (DM) and chronic kidney disease (CKD).

Background CI-AKI is an important complication after contrast medium injection. While small studies have shown positive results with statin therapy, the role of statin therapy in prevention of CI-AKI remains unknown.

Methods We randomized 2,998 patients with type 2 DM and concomitant CKD who were undergoing coronary/peripheral arterial angiography with or without percutaneous intervention to receive rosuvastatin, 10 mg/day (n 1,498), for 5 days (2 days before, and 3 days after procedure) or standard-of-care (n 1,500). Patients′ renal function was assessed at baseline, 48 h, and 72 h after exposure to contrast medium. The primary endpoint of the study was the development of CI-AKI, which was defined as an increase in serum creatinine concentration >= 0.5 mg/dl (44.2 mu mol/l) or 0.25% above baseline at 72 h after exposure to contrast medium.

Results Patients randomized to the rosuvastatin group had a significantly lower incidence of CI-AKI than controls (2.3% vs. 3.9%, respectively; p 0.01). During 30 days′ follow-up, the rate of worsening heart failure was significantly lower in the patients treated with rosuvastatin than that in the control group (2.6% vs. 4.3%, respectively; p 0.02).

Conclusions Rosuvastatin significantly reduced the risk of CI-AKI in patients with DM and CKD undergoing arterial contrast medium injection. (Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes [TRACK-D]; NCT00786136) (C) 2014 by the American College of Cardiology Foundation

语种: 英语
WOS记录号: WOS:000329838300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54043
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Armed Police Forces, Gen Hosp, Dept Cardiol, Beijing, Peoples R China
2.Lanzhou Mil WuluMuqi PLA Hosp, Dept Cardiol, Urumqi, Peoples R China
3.Jinan Mil Gen Hosp, Dept Cardiol, Jinan, Peoples R China
4.Wuhan Gen Hosp Guangzhou Mil, Dept Cardiol, Wuhan, Peoples R China
5.Shenyang Northern Hosp, Dept Cardiol, Shenyang 110016, Peoples R China
6.WuHan Asia Heart Hosp, Dept Cardiol, Wuhan, Peoples R China
7.CangZhou Cent Hosp, Dept Cardiol, CangZhou, Peoples R China
8.Shijiazhuang Int Peace Hosp, Dept Cardiol, Shijiazhuang, Peoples R China
9.Fushun Cent Hosp, Dept Cardiol, Fushun, Peoples R China
10.Changchun Cent Hosp, Dept Cardiol, Changchun, Peoples R China
11.Wenzhou Med Coll, Affiliated Hosp 1, Dept Cardiol, Wenzhou, Peoples R China
12.Armed Police Forces, Affiliated Hosp, Coll Med, Dept Cardiol, Tianjin, Peoples R China
13.Guangzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
14.Ningxia Med Coll, Affiliated Hosp, Dept Cardiol, Yinchuan, Peoples R China
15.Shanghai Jiao Tong Univ, Coll Med, Ruijin Hosp Affiliated, Dept Cardiol, Shanghai 200030, Peoples R China
16.Guangzhou Mil Command PLA, Gen Hosp, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
17.Fuwai Hosp, Cardiac Catheterizat Lab, Beijing, Peoples R China
18.Icahn Sch Med Mt Sinai, Zena & Michael A Weiner Cardiovasc Inst, New York, NY USA
19.Beijing Univ, Hosp 1, Dept Cardiol, Beijing, Peoples R China

Recommended Citation:
Han, Yaling,Zhu, Guoying,Han, Lixian,et al. Short-Term Rosuvastatin Therapy for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Diabetes and Chronic Kidney Disease[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2014,63(1):62-70.
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